DIAGNOSIS OF REGIONAL CEREBRAL BLOOD FLOW ABNORMALITIES USING SPECT: AGREEMENT BETWEEN INDIVIDUALIZED STATISTICAL PARAMETRIC MAPS AND VISUAL INSPECTION BY NUCLEAR MEDICINE PHYSICIANS WITH DIFFERENT LEVELS OF EXPERTISE IN NUCLEAR NEUROLOGY

被引：6

作者：

da Rocha, Euclides Timoteo ^{[1
,2
]}

Buchpiguel, Carlos Alberto ^{[3
]}

Nitrini, Ricardo ^{[4
]}

Tazima, Sergio ^{[5
]}

Peres, Stela Verzinhase ^{[6
]}

Busatto Filho, Geraldo ^{[7
]}

机构：

[1] Fundacao Pio XII, Hosp Canc, Dept Nucl Med, Barretos, SP, Brazil

[2] Sao Paulo State Univ, Ctr Blood Transfus, Sch Med, UNESP, Botucatu, SP, Brazil

[3] Hosp Coracao, Dept Nucl Med, Sao Paulo, Brazil

[4] Univ Sao Paulo, Fac Med, Dept Neurol, Sao Paulo, Brazil

[5] Hosp Alemao Oswaldo Cruz, Dept Nucl Med, Sao Paulo, Brazil

[6] Fundacao Pio XII, Hosp Canc, Res Support Grp, Barretos, SP, Brazil

[7] Univ Sao Paulo, Fac Med, Inst Psychiat, Dept Radiol,Nucl Med Div, Sao Paulo, Brazil

来源：

CLINICS | 2009年 / 64卷 / 12期

关键词：

Brain SPECT; ECD; Statistical parametric mapping; Cerebral blood flow; Dementia; TEMPORAL-LOBE EPILEPSY; OBSESSIVE-COMPULSIVE DISORDER; EMISSION COMPUTED-TOMOGRAPHY; ALZHEIMERS-DISEASE; BRAIN SPECT; CLINICAL VALIDATION; PERFUSION SPECT; HEAD-INJURY; PET IMAGES; FDG PET;

D O I：

10.1590/S1807-59322009001200003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

INTRODUCTION: Visual analysis is widely used to interpret regional cerebral blood flow (rCBF) SPECT images in clinical practice despite its limitations. Automated methods are employed to investigate between-group rCBF differences in research Studies but have rarely been explored in individual analyses. OBJECTIVES: To compare visual inspection by nuclear physicians with the automated statistical parametric mapping program using a SPECT dataset of patients with neurological disorders and normal control images. METHODS: Using statistical parametric mapping, 14 SPECT images from patients with various neurological disorders were compared individually with a databank of 32 normal images using a statistical threshold of p<0.05 (corrected for multiple comparisons at the level of individual voxels or clusters). Statistical parametric mapping results were compared with Visual analyses by a nuclear physician highly experienced in neurology (A) as well as a nuclear physician with a general background of experience (B) who independently classified images as normal or altered, and determined the location of changes and the severity. RESULTS: Of the 32 images of the normal databank, 4 generated maps showing rCBF abnormalities (p<0.05, corrected). Among the 14 images from patients with neurological disorders, 13 showed rCBF alterations. Statistical parametric mapping and physician A completely agreed on 84.37% and 64.28% of cases from the normal databank and neurological disorders, respectively. The agreement between statistical parametric mapping and ratings of physician B were lower (71.18% and 35.71%, respectively). CONCLUSION: Statistical parametric mapping replicated the findings described by the more experienced nuclear physician. This finding suggests that automated methods for individually analyzing rCBF SPECT images may be a valuable resource to complement visual inspection in clinical practice.

引用

页码：1145 / 1153

页数：9