Synthesis and Antimicrobial Activity of New 4-Methyl-2-(3-pyridyl)thiazolyl Chalcones and Pyrazolines

被引：6
作者：
Bondock, S. [1 ,2 ]
Nasr, T. [3 ]
机构：
[1] King Khalid Univ, Coll Sci, Chem Dept, Abha 9004, Saudi Arabia
[2] Mansoura Univ, Fac Sci, Chem Dept, Mansoura 35516, Egypt
[3] Helwan Univ, Fac Pharm, Dept Pharmaceut Chem, Cairo 11795, Egypt
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2021年 / 91卷 / 03期
关键词：
thiazole; pyridine; chalcone; pyrazoline; antibacterial activity; antifungal activity; THIAZOLES;
D O I：
10.1134/S1070363221030178
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In an attempt to develop active antimicrobial agents, a set of new thiazolyl chalcones has been synthesized by the Claisen-Schmidt reaction of 5-acetyl-4-methyl-2-(3-pyridyl)thiazole with various heterocyclic aldehydes in alkali media. Reaction of chalcones with hydrazine hydrate has resulted in pyrazolines that have been assessed for in vitro antimicrobial activity against ten bacterial and five fungal human pathogenic strains using the disk diffusion assay. The synthesized pyrazolines demonstrate antimicrobial activity higher than that of synthesized chalcones. 2-Thienylchalcone has been determined as the most active against P. aeruginosa. Three pyrazolines are characterized by distinctive activity towards Gram-negative bacteria S. flexneri and P. aeruginosa. Two pyrazolines demonstrate equipotent antifungal activity with amphotricin B against A. clavatus.
引用
收藏
页码：488 / 494
页数：7
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