The impact of TNF superfamily molecules on overall survival in acute myeloid leukaemia: correlation with biological and clinical features

被引：13

作者：

Bolkun, L. ^{[1
]}

Lemancewicz, D. ^{[1
,2
]}

Jablonska, E. ^{[3
]}

Szumowska, A. ^{[1
]}

Bolkun-Skornicka, U. ^{[4
]}

Ratajczak-Wrona, W. ^{[3
]}

Dzieciol, J. ^{[2
]}

Kloczko, J. ^{[1
]}

机构：

[1] Med Univ Bialystok, Dept Haematol, PL-15276 Bialystok, Poland

[2] Med Univ Bialystok, Dept Human Anat, PL-15276 Bialystok, Poland

[3] Med Univ Bialystok, Dept Immunol, PL-15276 Bialystok, Poland

[4] Med Univ Bialystok, Dept Pharmaceut Technol, PL-15276 Bialystok, Poland

来源：

ANNALS OF HEMATOLOGY | 2015年 / 94卷 / 01期

关键词：

Acute myeloid leukaemia; APRIL; BAFF; TRAIL; TUMOR-NECROSIS-FACTOR; CELL-ACTIVATING FACTOR; NF-KAPPA-B; LIGAND TRAIL; NEGATIVE REGULATOR; BAFF/APRIL SYSTEM; APOPTOSIS; EXPRESSION; DIAGNOSIS; RECOMMENDATIONS;

D O I：

10.1007/s00277-014-2178-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

B cell-activating factor (BAFF), a proliferation-inducing ligand (APRIL) and apoptosis-inducing ligand (TRAIL) were demonstrated in several haematological diseases including acute myeloid leukemia (AML). Those cytokines are capable of activating a broad spectrum of intracellular signalling cascades that can either induce apoptosis or protect from programmed cell death. We have analysed BAFF, APRIL and TRAIL serum concentrations in 76 patients with newly diagnosed AML and 40 healthy volunteers. The values were significantly higher for APRIL and BAFF but lower for TRAIL compared to healthy volunteers. Induction therapy significantly reduced the values for BAFF and increased them for TRAIL. Moreover, the concentration of BAFF and APRIL was significantly lower and the concentration of TRAIL higher in a group of patients with complete remission compared to non-respondent AML patients. In addition, higher concentrations of BAFF and lower of TRAIL predicted a shorter overall survival, suggesting thereby an important prognostic marker and possible therapeutic target in AML.

引用

页码：35 / 43

页数：9

共 40 条

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