Constitutively Active AR-V7 Plays an Essential Role in the Development and Progression of Castration-Resistant Prostate Cancer

被引：134

作者：

Qu, Yuanyuan ^{[1
,2
]}

Dai, Bo ^{[1
,2
]}

Ye, Dingwei ^{[1
,2
]}

Kong, Yunyi ^{[2
,3
]}

Chang, Kun ^{[1
,2
]}

Jia, Zhongwei ^{[1
,2
]}

Yang, Xiaoqun ^{[2
,3
]}

Zhang, Hailiang ^{[1
,2
]}

Zhu, Yao ^{[1
,2
]}

Shi, Guohai ^{[1
,2
]}

机构：

[1] Fudan Univ, Shanghai Canc Ctr, Dept Urol, Shanghai 200032, Peoples R China

[2] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200032, Peoples R China

[3] Fudan Univ, Shanghai Canc Ctr, Dept Pathol, Shanghai 200032, Peoples R China

来源：

SCIENTIFIC REPORTS | 2015年 / 5卷

基金：

中国国家自然科学基金;

关键词：

RECEPTOR SPLICE VARIANTS; ANDROGEN-RECEPTOR; CHINESE PATIENTS; HALF-LIFE; EXPRESSION; ANTIGEN; DEPRIVATION; ACTIVATION; PREDICTOR; THERAPY;

D O I：

10.1038/srep07654

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This study aimed to investigate the role of AR-V7 in development of castration-resistant prostate cancer (CRPC) and to determine whether the AR-V7 expression in CRPC tissues can predict cancer-specific survival. We enrolled 100 localized prostate cancer (PCa) (cohort 1), 104 newly diagnosed metastatic PCa (cohort 2), and 46 CRPC (cohort 3) patients treated at our institution. The expression of AR-V7 in PCa was assessed by immunohistochemistry. Cox regression models were used to evaluate the predictive role of all covariates for the development of CRPC in cohort 2 and for cancer-specific survival in cohort 3. Time to CRPC and cancer-specific survival curves were estimated using the Kaplan-Meier method. AR-V7 expression rate in cohort 3 was significantly elevated compared with other two cohorts (p < 0.001). Multivariate analysis revealed that AR-V7 was an independent predictive factor for CRPC development (HR = 2.627, p = 0.001) and for cancer specific survival (HR = 2.247, p = 0.033). Furthermore, the AR-V7 expression was associated with shorter survival in CRPC patients. Our results demonstrated protein AR-V7 levels in primary tumors can be used as a predictive marker for the development of CRPC and as a prognostic factor in CRPC patients. Therapy targeting AR-V7 may help prevent PCa progression and improve the prognosis of CRPC patients.

引用

页数：6

共 29 条

[1] Androgen receptor splice variants activating the full-length receptor in mediating resistance to androgen-directed therapy [J].