The Positive Predictive Value of Onconeural Antibody Testing: A Retrospective Review

被引：20

作者：

Budhram, Adrian ^{[1
]}

Nicolle, Michael W. ^{[1
]}

Yang, Liju ^{[2
]}

机构：

[1] London Hlth Sci Ctr, Dept Clin Neurol Sci, London, ON, Canada

[2] London Hlth Sci Ctr, Dept Pathol & Lab Med, London, ON, Canada

来源：

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES | 2018年 / 45卷 / 05期

关键词：

Paraneoplastic conditions; Paraneoplastic encephalomyelitis; Neuroimmunology; Neuro-oncology-medical;

D O I：

10.1017/cjn.2018.74

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Paraneoplastic syndromes (PNS) are immune-mediated neurologic diseases that occur as an indirect effect of malignancy, and can be challenging to diagnose. Onconeural antibodies have a greater than 95% association with cancer, and their presence in a patient with neurologic symptoms is reportedly highly indicative of PNS. However, we performed a single-centre retrospective review to determine the positive predictive value of onconeural antibody testing, and found it to be concerningly low (39%). Recognising the limitations of onconeural antibody testing is critical to ensure accurate test interpretation, avoid unnecessary repeated malignancy screening and prevent the use of potentially hazardous immunotherapy.

引用

页码：577 / 579

页数：3

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