The Positive Predictive Value of Onconeural Antibody Testing: A Retrospective Review

被引：18
作者：
Budhram, Adrian [1 ]
Nicolle, Michael W. [1 ]
Yang, Liju [2 ]
机构：
[1] London Hlth Sci Ctr, Dept Clin Neurol Sci, London, ON, Canada
[2] London Hlth Sci Ctr, Dept Pathol & Lab Med, London, ON, Canada
来源：
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES | 2018年 / 45卷 / 05期
关键词：
Paraneoplastic conditions; Paraneoplastic encephalomyelitis; Neuroimmunology; Neuro-oncology-medical;
D O I：
10.1017/cjn.2018.74
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Paraneoplastic syndromes (PNS) are immune-mediated neurologic diseases that occur as an indirect effect of malignancy, and can be challenging to diagnose. Onconeural antibodies have a greater than 95% association with cancer, and their presence in a patient with neurologic symptoms is reportedly highly indicative of PNS. However, we performed a single-centre retrospective review to determine the positive predictive value of onconeural antibody testing, and found it to be concerningly low (39%). Recognising the limitations of onconeural antibody testing is critical to ensure accurate test interpretation, avoid unnecessary repeated malignancy screening and prevent the use of potentially hazardous immunotherapy.
引用
收藏
页码：577 / 579
页数：3
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