Signal transducer and activator of transcription (STAT) signalling and T-cell lymphomas

被引：128
作者：
Mitchell, TJ
John, S [1 ]
机构：
[1] Kings Coll London, Dept Immunobiol, Programme Infect & Immun, London WC2R 2LS, England
[2] Kings Coll London, St Johns Inst Dermatol, Skin Tumor Unit, London WC2R 2LS, England
来源：
IMMUNOLOGY | 2005年 / 114卷 / 03期
基金：
英国医学研究理事会;
关键词：
negative regulation; phophatases; STATs; T-cell lymphoma; truncated STATs;
D O I：
10.1111/j.1365-2567.2005.02091.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Interaction of cytokines with their cognate receptors leads to the activation of latent transcription factors - the signal transducers and activators of transcription (STAT) proteins - whose biological activities ultimately regulate many critical aspects of cell growth, survival and differentiation. Dysregulation of the JAK-STAT pathway is frequently observed in many primary human tumours, reflecting the importance of this pathway in the maintenance of cellular integrity. Here we review the current progress in STAT structure and function, and the contribution of STAT signalling to the pathogenesis of T-cell lymphomas.
引用
收藏
页码：301 / 312
页数：12
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