Mechanism of activation and function of protein kinase B

被引：662

作者：

Alessi, DR ^{[1
]}

Cohen, P ^{[1
]}

机构：

[1] Univ Dundee, Dept Biochem, MRC, Prot Phosphorylat Unit, Dundee DD1 4HN, Scotland

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1998年 / 8卷 / 01期

关键词：

D O I：

10.1016/S0959-437X(98)80062-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The past year has seen significant advances in our understanding of how protein kinase B (PKB) is activated and of the central role it plays in insulin signalling and in mediating the protective effects of survival factors against apoptosis. The highlights include the discovery of a protein kinase required for the 3-phosphoinositide-dependent activation of PKB and the identification of several physiological substrates for PKB.

引用

页码：55 / 62

页数：8

共 55 条

[1] Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase [J].

Ahmed, NN ;

Grimes, HL ;

Bellacosa, A ;

Chan, TO ;

Tsichlis, PN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (08) :3627-3632

[2] Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha [J].

Alessi, DR ;

James, SR ;

Downes, CP ;

Holmes, AB ;

Gaffney, PRJ ;

Reese, CB ;

Cohen, P .

CURRENT BIOLOGY, 1997, 7 (04) :261-269

[3] Molecular basis for the substrate specificity of protein kinase B; Comparison with MAPKAP kinase-1 and p70 S6 kinase [J].

Alessi, DR ;

Caudwell, FB ;

Andjelkovic, M ;

Hemmings, BA ;

Cohen, P .

FEBS LETTERS, 1996, 399 (03) :333-338

[4] 3-phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase [J].

Alessi, DR ;

Deak, M ;

Casamayor, A ;

Caudwell, FB ;

Morrice, N ;

Norman, DG ;

Gaffney, P ;

Reese, CB ;

MacDougall, CN ;

Harbison, D ;

Ashworth, A ;

Bownes, M .

CURRENT BIOLOGY, 1997, 7 (10) :776-789

[5] PD-098059 IS A SPECIFIC INHIBITOR OF THE ACTIVATION OF MITOGEN-ACTIVATED PROTEIN-KINASE KINASE IN-VITRO AND IN-VIVO [J].

ALESSI, DR ;

CUENDA, A ;

COHEN, P ;

DUDLEY, DT ;

SALTIEL, AR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (46) :27489-27494

[6] Mechanism of activation of protein kinase B by insulin and IGF-1 [J].

Alessi, DR ;

Andjelkovic, M ;

Caudwell, B ;

Cron, P ;

Morrice, N ;

Cohen, P ;

Hemmings, BA .

EMBO JOURNAL, 1996, 15 (23) :6541-6551

[7] 3 Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro [J].

Alessi, DR ;

Kozlowski, MT ;

Weng, QP ;

Morrice, N ;

Avruch, J .

CURRENT BIOLOGY, 1998, 8 (02) :69-81

[8] Role of translocation in the activation and function of protein kinase B [J].

Andjelkovic, M ;

Alessi, DR ;

Meier, R ;

Fernandez, A ;

Lamb, NJC ;

Frech, M ;

Cron, P ;

Cohen, P ;

Lucocq, JM ;

Hemmings, BA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (50) :31515-31524

[9] A constitutively active version of the Ser/Thr kinase Akt induces production of the ob gene product, leptin, in 3T3-L1 adipocytes [J].

Barthel, A ;

Kohn, AD ;

Luo, YN ;

Roth, RA .

ENDOCRINOLOGY, 1997, 138 (08) :3559-3562

[10]

BELACOSSA A, 1991, SCIENCE, V254, P244

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