Effects of Keratinocyte Growth Factor-2 on Corneal Epithelial Wound Healing in a Rabbit Model of Carbon Dioxide Laser Injury

被引：22

作者：

Wang, Xiaojie ^{[2
,3
]}

Zhou, Xin ^{[3
]}

Ma, Jisheng ^{[2
,3
]}

Tian, Haishan ^{[3
]}

Jiao, Yue ^{[3
]}

Zhang, Rui ^{[3
]}

Huang, Zhifeng ^{[4
]}

Xiao, Jian ^{[4
]}

Zhao, Binhai ^{[2
]}

Qian, Huanwen ^{[1
]}

Li, Xiaokun ^{[2
,3
,4
]}

机构：

[1] Acad Mil Med Sci, Inst Radiat Med, Beijing 100850, Peoples R China

[2] Jilin Univ, Sch Publ Hlth, Changchun 130021, Peoples R China

[3] Jilin Agr Univ, Biopharmaceut & Bioreactor Res Ctr, Minist Educ, Changchun 130118, Peoples R China

[4] Wenzhou Med Coll, Key Lab Biotechnol Pharmaceut Engn, Wenzhou 325035, Peoples R China

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2010年 / 33卷 / 06期

关键词：

keratinocyte growth factor-2; corneal; epithelium; wound healing; ALPHA MESSENGER-RNA; TOPICAL APPLICATION; MOUSE LUNG; CELLS; PROLIFERATION; MIGRATION; PROTEIN; PHASES; ULCERS; REPAIR;

D O I：

10.1248/bpb.33.971

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Keratinocyte growth factor-2 (KGF-2), also called fibroblast growth factor-10 (FGF-10), is a member of the fibroblast growth factor family. It plays a critical role in epithelial development and exerts its biological activities in a paracrine manner on the receptor FGFR2-IIIb. This study examined the function of topically applied KGF2 in viva on wound healing using a CO2 laser, corneal epithelial wounded, rabbit model. Topically applied 25 mu g/ml KGF-2 accelerated corneal epithelial wound healing, in contrast to the control, and reduced inflammation, stromal edema, and fibrosis. In addition, this factor also exhibited significant inhibition of corneal neovas-cularization. KGF-2 appears to be another important growth factor in the regulation of corneal epithelial wound healing.

引用

页码：971 / 976

页数：6

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