Is type 2 diabetes an amyloidosis and does it really matter (to patients)?

被引:26
作者
Cooper, G. J. S. [1 ,2 ,3 ]
Aitken, J. F. [1 ,2 ]
Zhang, S. [1 ,2 ]
机构
[1] Univ Auckland, Sch Biol Sci, Fac Sci, Auckland 1, New Zealand
[2] Univ Auckland, Maurice Wilkins Ctr Excellence Mol Biodiscovery, Fac Sci, Auckland 1, New Zealand
[3] Univ Oxford, Dept Pharmacol, Div Med Sci, Oxford OX1 3QT, England
关键词
BETA-CELL APOPTOSIS; GENE-RELATED PEPTIDE; HUMAN AMYLIN; TRANSGENIC MICE; POLYPEPTIDE; PROTEIN; ISLETS; FIBRILS; INSULIN; ACTIVATION;
D O I
10.1007/s00125-010-1715-y
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1011 / 1016
页数:6
相关论文
共 56 条
[1]   Tetracycline Treatment Retards the Onset and Slows the Progression of Diabetes in Human Amylin/Islet Amyloid Polypeptide Transgenic Mice [J].
Aitken, Jacqueline F. ;
Loomes, Kerry M. ;
Scott, David W. ;
Reddy, Shivanand ;
Phillips, Anthony R. J. ;
Prijic, Gordana ;
Fernando, Chathurini ;
Zhang, Shaoping ;
Broadhurst, Ric ;
L'Huillier, Phil ;
Cooper, Garth J. S. .
DIABETES, 2010, 59 (01) :161-171
[2]   Suppression by polycyclic compounds of the conversion of human amylin into insoluble amyloid [J].
Aitken, JF ;
Loomes, KM ;
Konarkowska, B ;
Cooper, GJS .
BIOCHEMICAL JOURNAL, 2003, 374 :779-784
[3]   Expression of neuronal traits in pancreatic beta cells - Implication of neuron-restrictive silencing factor/repressor element silencing transcription factor, a neuron-restrictive silencer [J].
Atouf, F ;
Czernichow, P ;
Scharfmann, R .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (03) :1929-1934
[4]  
BELL ET, 1959, AM J PATHOL, V35, P801
[5]   HYALINIZATION OF THE ISLETS OF LANGERHANS IN DIABETES MELLITUS [J].
BELL, ET .
DIABETES, 1952, 1 (05) :341-344
[6]  
BENSON MD, 1989, METABOLIC BASIS INHE, V2, P2439
[7]   β-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes [J].
Butler, AE ;
Janson, J ;
Bonner-Weir, S ;
Ritzel, R ;
Rizza, RA ;
Butler, PC .
DIABETES, 2003, 52 (01) :102-110
[8]   Doxycycline disrupts transthyretin amyloid: evidence from studies in a FAP transgenic mice model [J].
Cardoso, I. ;
Saraiva, M. J. .
FASEB JOURNAL, 2006, 20 (02) :234-239
[9]  
CLARK A, 1988, DIABETES RES CLIN EX, V9, P151
[10]  
CLARK A, 1987, LANCET, V2, P231