Novel environmentally benign procedure for the synthesis of 2-aryl- and 2-hetaryl-4(3H)-quinazolinones

被引：13

作者：

Deligeorgiev, T. G. ^{[1
]}

St Kaloyanova ^{[1
]}

Vasilev, A. ^{[1
]}

Vaquero, J-J ^{[2
]}

Alvarez-Builla, J. ^{[2
]}

Cuadro, Ana M. ^{[2
]}

机构：

[1] Univ Sofia, Fac Chem, Sofia 1164, Bulgaria

[2] Univ Alcala de Henares, Fac Pharm, Madrid 28871, Spain

来源：

COLORATION TECHNOLOGY | 2010年 / 126卷 / 01期

关键词：

ONE-POT SYNTHESIS; BIOLOGICAL EVALUATION; AGENTS;

D O I：

10.1111/j.1478-4408.2010.00223.x

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A novel environmentally benign procedure for the synthesis of 2-aryl- or 2-hetaryl-4(3H)-quinazolinones by condensation of anthranilamide with various aromatic aldehydes in polyethylene glycol under microwave irradiation has been developed. In contrast with other reported methods, this procedure provides the corresponding quinazolinones with good to high yields and purity, in very short reaction times and without the use of an oxidant.

引用

收藏

页码：24 / 30

页数：7

相关论文

共 25 条

[1] A novel method for the synthesis of 4(3H)-quinazolinones [J].

Abdel-Jalil, RJ ;

Voelter, W ;

Saeed, M .

TETRAHEDRON LETTERS, 2004, 45 (17) :3475-3476

[2] One pot synthesis of 4(3H)-quinazolinones [J].

Bhat, BA ;

Sahu, DP .

SYNTHETIC COMMUNICATIONS, 2004, 34 (12) :2169-2176

[3] Substituted isoquinolines and quinazolines as potential antiinflammatory agents.: Synthesis and biological evaluation of inhibitors of tumor necrosis factor α [J].

Chao, Q ;

Deng, L ;

Shih, HC ;

Leoni, LM ;

Genini, D ;

Carson, DA ;

Cottam, HB .

JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (19) :3860-3873

[4] Polyethylene glycol and solutions of polyethylene glycol as green reaction media [J].

Chen, J ;

Spear, SK ;

Huddleston, JG ;

Rogers, RD .

GREEN CHEMISTRY, 2005, 7 (02) :64-82

[5]

Connolly DJ, 2001, SYNLETT, P1707

[6] One-pot synthesis of mono- and disubstituted (3H)-quinazolin-4-ones in dry media under microwave irradiation [J].

Dabiri, M ;

Salehi, P ;

Mohammadi, AA ;

Baghbanzadeh, M .

SYNTHETIC COMMUNICATIONS, 2005, 35 (02) :279-287

[7] One-step synthesis of 4(3H)-quinazolinones [J].

Deetz, MJ ;

Malerich, JP ;

Beatty, AM ;

Smith, BD .

TETRAHEDRON LETTERS, 2001, 42 (10) :1851-1854

[8] Niementowski reaction: microwave induced and conventional synthesis of quinazolinones and 3-methyl-1H-5-pyrazolones and their antimicrobial activity [J].

Desai, AR ;

Desai, KR .

ARKIVOC, 2005, :98-108

[9]

Dinakaran M, 2003, BIOL PHARM BULL, V26, P1278

[10] Rapid N-alkylation of carbazole, phenothiazine and acridone under microwave irradiation [J].

Fan, XJ ;

You, JM ;

Jiao, TQ ;

Tan, GZ ;

Yu, XD .

ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 2000, 32 (03) :284-287