Roles of Reactive Nitrogen Species in Ischemic Stroke

被引:0
作者
Zhang Pan [1 ]
Yan Wei-Jie [2 ]
Zhao Yu-Ming [2 ]
机构
[1] Capital Med Univ, Dept Clin Med, Beijing 100069, Peoples R China
[2] Capital Med Univ, Dept Pharmacol, Sch Basic Med Sci, Beijing 100069, Peoples R China
基金
北京市自然科学基金; 中国国家自然科学基金;
关键词
reactive nitrogen species; reactive oxygen species; stroke; cerebral ischemia-reperfusion injury; NITRIC-OXIDE SYNTHASE; BLOOD-BRAIN-BARRIER; FOCAL CEREBRAL-ISCHEMIA; REPERFUSION INJURY; ENDOTHELIAL-CELLS; S-NITROSYLATION; CAVEOLIN-1; EXPRESSION; NITROSATIVE STRESS; LIVING CELLS; REDOX CYCLES;
D O I
10.16476/j.pibb.2016.0309
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Small molecules of free radicals play essential roles in maintaining normal physiological function in organisms. However, in a variety of pathological conditions, excessive accumulation of these substances might cause serious damage to tissues and organs due to their highly active, strong oxidization properties. For instance, reactive oxygen species (ROS) and reactive nitrogen species (RNS), two major small molecules active substances, are proved to participate in the pathogenesis of stroke. In particular, the role of reactive nitrogen in stroke onset is one of the hot spot in current stroke etiology study. In this publication, recent progress of the physical and pathological functions of RNS in stroke study are reviewed and prospected.
引用
收藏
页码:398 / 406
页数:9
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