Emerging novel drug delivery strategies for bioactive flavonol fisetin in biomedicine

被引：65

作者：

Mehta, Piyush ^{[1
]}

Pawar, Atmaram ^{[2
]}

Mahadik, Kakasaheb ^{[3
]}

Bothiraja, C. ^{[2
]}

机构：

[1] Bharati Vidyapeeth Deemed Univ, Poona Coll Pharm, Dept Qual Assurance Tech, Pune 411038, Maharashtra, India

[2] Bharati Vidyapeeth Deemed Univ, Poona Coll Pharm, Dept Pharmaceut, Pune 411038, Maharashtra, India

[3] Bharati Vidyapeeth Deemed Univ, Poona Coll Pharm, Dept Pharmaceut Chem, Pune 411038, Maharashtra, India

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2018年 / 106卷

关键词：

Fisetin; Geraldol; Drug delivery; Phytoconstituents; Pharmacokinetic profile; IN-VITRO; IMPROVES BIOAVAILABILITY; LIPID NANOPARTICLES; POLYMERIC MICELLES; FORMULATION; COMPLEXATION; ANTIOXIDANT; METABOLISM; INJURY; CELLS;

D O I：

10.1016/j.biopha.2018.07.079

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Fisetin (FIS), a bioactive flavonol found in the smoke tree (Cotinus coggygria), vegetables, fruits and nuts. It exhibits various therapeutic activities such as anti-oxidant, anti-inflammatory, anti-invasive, anti-tumorigenic, anti-angiogenic, anti-diabetic, cardioprotective and neuroprotective activities. In spite of the ever rising support for therapeutic activities, its clinical application is mainly limited because of poor water solubility, high lipophilicity and low oral bioavailability. Till date, numerous efforts have been made to surpass these limitations with the development of new improved delivery platforms. This article aims to review and analyze the various delivery strategies used to improve the biopharmaceutical properties of FIS. Furthermore, an attempt has been made to touch upon various features related to the progress of drug delivery including their influence on FIS chemistry, pharmacokinetics and other physicochemical attributes are discussed thoroughly.

引用

页码：1282 / 1291

页数：10

共 63 条

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