Mirtazapine prevents induction and expression of cocaine-induced behavioral sensitization in rats

被引：38

作者：

Salazar-Juarez, Alberto ^{[1
]}

Barbosa-Mendez, Susana ^{[1
]}

Jurado, Noe ^{[1
]}

Hernandez-Miramontes, Ricardo ^{[1
]}

Leff, Philippe ^{[1
]}

Anton, Benito ^{[1
]}

机构：

[1] Inst Nacl Psiquiatria, Lab Neurobiol Mol & Neuroquim Adicc, Subdirecc Invest Clin, Mexico City 14370, DF, Mexico

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2016年 / 68卷

关键词：

Mirtazapine; Cocaine; Pharmacotherapy; Locomotor sensitization; Drug addiction; 5-HT receptors; Alpha receptors; 5-HT3 RECEPTOR ANTAGONIST; CONDITIONED PLACE PREFERENCE; DOPAMINE RELEASE; EXTRACELLULAR DOPAMINE; SEROTONERGIC SYSTEM; LOCOMOTOR-ACTIVITY; PREFRONTAL CORTEX; NUCLEUS-ACCUMBENS; D-2/D-3; RECEPTORS; CONTROLLED-TRIAL;

D O I：

10.1016/j.pnpbp.2016.02.010

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cocaine abuse is a major health problem worldwide. Treatment based on both 5-HT2A/C and 5-HT3 receptor antagonists attenuate not only the effects of cocaine abuse but also the incentive/motivational effect related to cocaine-paired cues. Mirtazapine, an antagonist of postsynaptic alpha(2)-adrenergic, 5-HT2A/C and 5HT(3) receptors and inverse agonist of the 5-HT2C receptor, has been shown to effectively modify, at the preclinical and clinical levels, various behavioral alterations induced by drugs abuse. Therefore, it is important to assess whether chronic dosing of mirtazapine alters locomotor effects of cocaine as well as induction and expression of cocaine sensitization. Our results reveal that a daily mirtazapine regimen administered for 30 days effectively induces a significant attenuation of cocaine-dependent locomotor activity and as well as the induction and expression of behavioral sensitization. These results suggest that mirtazapine may be used as a potentially effective therapy to attenuate induction and expression of cocaine-induced locomotor sensitization. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：15 / 24

页数：10

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