NO inhibitory diterpenoids as potential anti-inflammatory agents from Euphorbia antiquorum

被引：24
作者：
An, Lijun [1 ,2 ]
Liang, Yue [1 ,2 ]
Yang, Xueyuan [1 ,2 ]
Wang, Huimei [1 ,2 ]
Zhang, Jie [3 ]
Tuerhong, Muhetaer [4 ]
Li, Dihua [5 ]
Wang, Chunyan [6 ]
Lee, Dongho [7 ]
Xu, Jing [1 ,2 ]
Shuai, Ling [1 ,2 ]
Jin, Jin [1 ,2 ]
Guo, Yuanqiang [1 ,2 ,8 ]
机构：
[1] Nankai Univ, State Key Lab Med Chem Biol, Coll Pharm, Tianjin Key Lab Mol Drug Res, Tianjin 300350, Peoples R China
[2] Nankai Univ, Drug Discovery Ctr Infect Dis, Tianjin 300350, Peoples R China
[3] Shihezi Univ, Sch Chem & Chem Engn, Key Lab Green Proc Chem Engn Xinjiang Bingtuan, Shihezi 832003, Peoples R China
[4] Kashgar Univ, Lab Xinjiang Nat Med & Edible Plant Resources Che, Coll Chem & Environm Sci, Kashgar 844000, Peoples R China
[5] Nankai Univ, Nankai Hosp, Tianjin Inst Acute Abdominal Dis Integrated Tradi, Tianjin 300100, Peoples R China
[6] Tianjin Second Peoples Hosp, Tianjin 300192, Peoples R China
[7] Korea Univ, Coll Life Sci & Biotechnol, Dept Biosyst & Biotechnol, Seoul 136713, South Korea
[8] Guangxi Normal Univ, State Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China
来源：
BIOORGANIC CHEMISTRY | 2019年 / 92卷
基金：
中国国家自然科学基金;
关键词：
NO inhibitory effects; Euphorbia antiquorum; Diterpenoids; Inflammation; Molecular docking; STRUCTURALLY DIVERSE DITERPENOIDS; ANTI-NEUROINFLAMMATORY AGENTS; INGOL-TYPE DITERPENES; JATROPHANE DITERPENOIDS; TIGLIANE DITERPENOIDS; BIOLOGICAL EVALUATION; MULTIDRUG-RESISTANCE; ROOTS; LATEX; ESTERS;
D O I：
10.1016/j.bioorg.2019.103237
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two new ent-atisane-type diterpenoids (1 and 2), three new lathyrane-type diterpenoids (3-5), and seven known analogues (6-12) were isolated from Euphorbia antiquorum. The structures of these diterpenoids were established by analysis of their NMR, MS, and electronic circular dichroism data. The anti-inflammatory activities were evaluated biologically and compounds 1, 4, 7, 8, and 10 displayed strong NO inhibitory effects with IC50, values less than 40 mu M. The potential anti-inflammatory mechanism was also investigated using molecular docking and Western blotting.
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页数：10
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