From rapalogs to anti-aging formula

被引：59
作者：
Blagosklonny, Mikhail V. [1 ]
机构：
[1] Roswell Pk Canc Inst, Cell Stress Biol, Buffalo, NY 14263 USA
来源：
ONCOTARGET | 2017年 / 8卷 / 22期
关键词：
lifespan; longevity; rejuvenation; health; diseases; EXTENDS LIFE-SPAN; CONVERTING ENZYME-INHIBITORS; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; SELECTIVE ANTICANCER AGENTS; ORGAN TRANSPLANT RECIPIENTS; HER-2/NEU TRANSGENIC MICE; DIETARY RESTRICTION; CANCER PREVENTION; CELLULAR SENESCENCE; CARDIOVASCULAR-DISEASE;
D O I：
10.18632/oncotarget.18033
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Inhibitors of mTOR, including clinically available rapalogs such as rapamycin (Sirolimus) and Everolimus, are gerosuppressants, which suppress cellular senescence. Rapamycin slows aging and extends life span in a variety of species from worm to mammals. Rapalogs can prevent age-related diseases, including cancer, atherosclerosis, obesity, neurodegeneration and retinopathy and potentially rejuvenate stem cells, immunity and metabolism. Here, I further suggest how rapamycin can be combined with metformin, inhibitors of angiotensin II signaling (Losartan, Lisinopril), statins (simvastatin, atorvastatin), propranolol, aspirin and a PDE5 inhibitor. Rational combinations of these drugs with physical exercise and an anti-aging diet (Koschei formula) can maximize their anti-aging effects and decrease side effects.
引用
收藏
页码：35492 / 35507
页数：16
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