Total Synthesis of Cryptocaryol A by Enantioselective Iridium-Catalyzed Alcohol C-H Allylation

被引：17

作者：

Perez, Felix ^{[1
]}

Waldeck, Andrew R. ^{[1
]}

Krische, Michael J. ^{[1
]}

机构：

[1] Univ Texas Austin, Dept Chem, 105 E 24th St A5300, Austin, TX 78712 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 16期

关键词：

enantioselective synthesis; iridium; polyketide; total synthesis; transfer hydrogenation; TUMOR-SUPPRESSOR PDCD4; ALDEHYDE OXIDATION LEVEL; WACKER-TYPE OXIDATION; CARBONYL ALLYLATION; TRANSFORMATION SUPPRESSOR; 1,5-ASYMMETRIC INDUCTION; STRUCTURE ELUCIDATION; CROTYLATION; ACETATE; EXPRESSION;

D O I：

10.1002/anie.201600591

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The polyketide natural product cryptocaryolA is prepared in 8 steps via iridium catalyzed enantioselective diol double C-H allylation, which directly generates an acetate-based triketide stereodiad. In 4 previously reported total syntheses, 17-28 steps were required.

引用

页码：5049 / 5052

页数：4

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