A convenient, highly selective and eco-friendly N-Boc protection of pyrimidines under microwave irradiation

被引：10

作者：

Bessieres, Maxime ^{[1
]}

Roy, Vincent ^{[1
]}

Agrofoglio, Luigi A. ^{[1
]}

机构：

[1] Univ Orleans, ICOA, UMR CNRS 7311, Orleans, France

来源：

RSC ADVANCES | 2014年 / 4卷 / 104期

关键词：

EFFICIENT SYNTHESIS; TERT-BUTYLOXYCARBONYLATION; ACID; SOLVENT;

D O I：

10.1039/c4ra13033b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Protected pyrimidine nucleobases are of major importance as intermediates in the synthesis of nucleoside analogues and molecules with biological interests. We describe herein a novel practical microwave-assisted N-Boc protection of pyrimidine nucleobases under mild conditions using silica gel, avoiding treatment steps, and in increased yield.

引用

页码：59747 / 59749

页数：3

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