The role of new eudesmane-type sesquiterpenoid and known eudesmane derivatives from the red alga Laurencia obtusa as potential antifungal-antitumour agents

被引：26

作者：

Alarif, Walied M. ^{[1
]}

Al-Footy, Khalid O. ^{[2
]}

Zubair, Muhammad Sulaiman ^{[2
,3
]}

Halid, Mohamed P. H. ^{[2
]}

Ghandourah, Mohamed A. ^{[1
]}

Basaif, Salim A. ^{[2
]}

Al-Lihaibi, Sultan S. ^{[1
]}

Ayyad, Seif-Eldin N. ^{[2
,4
]}

Badria, Farid A. ^{[5
]}

机构：

[1] King Abdulaziz Univ, Dept Marine Chem, Fac Marine Sci, POB 80207, Jeddah 21589, Saudi Arabia

[2] King Abdulaziz Univ, Dept Chem, Fac Sci, POB 80203, Jeddah 21589, Saudi Arabia

[3] Tadulako Univ, Dept Pharm, Fac Sci, Kampus Bumi Tadulako Tondo, Palu 94118, Indonesia

[4] Damietta Univ, Dept Chem, Fac Sci, Dumyat, Egypt

[5] Mansoura Univ, Dept Pharmacognosy, Fac Pharm, Mansoura 35516, Egypt

来源：

NATURAL PRODUCT RESEARCH | 2016年 / 30卷 / 10期

关键词：

red algae; terpenoids; eudesmanes; cytotoxicity; antifungal activity; LACTATE-DEHYDROGENASE; NATURAL-PRODUCTS; EXTRACTS;

D O I：

10.1080/14786419.2015.1046378

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new eudesmane sesquiterpenoid, eudesma-4(15),7-diene-5,11-diol (1) along with the known trinor-sesquiterene, teuhetenone (2), and a seco-eudesmane sesquiterpene, chabrolidione B (3), have been isolated from the Red Sea red alga Laurencia obtusa. The chemical structures were elucidated on the basis of extensive spectroscopic analysis. The antifungal and cytotoxic activities of the isolated metabolites were tested against several fungi, yeast and human mammary carcinoma cell line (MCF-7). Compounds 1 and 3 showed a much better activity [minimum inhibitory concentration (MIC): 2.9M] than that of amphotericin B (MIC: 4.6M). Interestingly, compound 2, the least active antifungal compound, retained the high anticancer activity against MCF-7 (22M) in comparison with cisplatin (59M), which was determined by employing lactate dehydrogenase assay. Compounds 1-3 are recorded here for the first time from algal flora. The chemotaxonomic importance of the isolated metabolites was discussed.

引用

页码：1150 / 1155

页数：6

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