Two tirucallane derivatives from Paramignya scandens and their cytotoxic activity

被引：9

作者：

Nguyen Huu Toan Phan ^{[1
]}

Nguyen Thi Dieu Thuan ^{[1
]}

Ninh Thi Ngoc ^{[2
]}

Pham Thi Mai Huong ^{[2
]}

Nguyen Phuong Thao ^{[2
]}

Nguyen Xuan Cuong ^{[2
]}

Nguyen Van Thanh ^{[2
]}

Nguyen Hoai Nam ^{[2
]}

Phan Van Kiem ^{[2
]}

Chau Van Minh ^{[2
]}

机构：

[1] Vietnam Acad Sci & Technol, Tay Nguyen Inst Sci Res, Da Lat, Vietnam

[2] VAST, Inst Marine Biochem, Hanoi, Vietnam

来源：

PHYTOCHEMISTRY LETTERS | 2014年 / 9卷

关键词：

Paramignya scandens; Rutaceae; Tirucallane; Cytotoxic activity; TRITERPENOIDS; MONOPHYLLA; COUMARINS; BARK;

D O I：

10.1016/j.phytol.2014.04.011

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Various chromatographic separations of the methanolic extract of Paramignya scandens stem and leaves resulted in the isolation of two new tirucallane derivatives, paramignyols A and B (1 and 2). Their structures were established by HR-ESI-MS, 1D and 2D NMR experiments, as well as, comparison with literature data. Compounds 1 and 2 showed significant cytotoxic activity (IC(50)s similar to 3.55-10.50 mu M) on four tested human cancer cell lines: KB (epidermoid carcinoma), SK-Mel-2 (melanoma), LU-1 (lung adenocarcinoma), and MCF7 (breast cancer). This is the first report on chemical constituents and biological activities of P. scandens. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

引用

页码：78 / 81

页数：4

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