Mitigating the Cytotoxicity of Graphene Quantum Dots and Enhancing Their Applications in Bioimaging and Drug Delivery

被引：93

作者：

Chandra, Anil ^{[1
,2
]}

Deshpande, Sonal ^{[1
,2
]}

Shinde, Dhanraj B. ^{[3
]}

Pillai, Vijayamohanan K. ^{[4
]}

Singh, Neetu ^{[1
,2
]}

机构：

[1] Indian Inst Technol Delhi, Ctr Biomed Engn, New Delhi 110016, India

[2] Natl Chem Lab, Div Polymer Sci & Engn, Pune 411008, Maharashtra, India

[3] Natl Chem Lab, Phys & Mat Chem Div, Pune 411008, Maharashtra, India

[4] Cent Electrochem Res Inst, Karaikkudi 630006, Tamil Nadu, India

来源：

ACS MACRO LETTERS | 2014年 / 3卷 / 10期

关键词：

IN-VITRO; OXIDE; SIZE; CELLS; GRAPHITE; ACID;

D O I：

10.1021/mz500479k

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Despite the promising photophysical properties of fluorescent graphene quantum dots (GQDs), their cellular toxicity needs to be addressed before their full potential could be completely realized in biomedicine. A simple method for mitigating the toxicity of GQDs by embedding them in PEG matrix is reported here. The enhanced biocompatibility of polymer modified, P-GQDs, is attributed to reduced reactive oxygen species generation, as measured by an intracellular ROS assay. We also demonstrate the enhanced loading and efficient intracellular delivery of therapeutics by P-GQDs.

引用

页码：1064 / 1068

页数：5

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