Expression of stromelysin-3 in medullary carcinoma of the breast

被引：0
|
作者：
Holm, R [1 ]
Florenes, VA
Erikstein, B
Nesland, JM
机构：
[1] Norwegian Radium Hosp, Dept Pathol, N-0310 Oslo, Norway
[2] Norwegian Radium Hosp, Dept Tumorbiol, N-0310 Oslo, Norway
[3] Norwegian Radium Hosp, Dept Med Oncol, N-0310 Oslo, Norway
[4] Inst Canc Res, N-0310 Oslo, Norway
来源：
ANTICANCER RESEARCH | 1997年 / 17卷 / 5B期
关键词：
breast; in situ hybridization; medullary carcinomas; stromelysin-3;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Matrix metalloproteinases are belived to play a central role in the invasion and metastasis of human cancers by mediating the degration of extracellular matrix components. Expression of stromelysin-3 (ST3), a new member of matrix metalloproteinase family, was investigated by in situ hybridization in 32 tissue samples of medullary carcinoma of the breast. Eighty-four per cent of the cases showed ST3 gene expression in stromal cells adjacent to tumor cells. Therefore, expression of ST3 in stromal cells may be expected to play a significant role in the destruction of extracellular matrix and invasion of medullary carcinoma of the breast.
引用
收藏
页码：3725 / 3727
页数：3
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