Are genetic and sporadic Parkinson's disease patients equally susceptible to develop dementia?

被引：8
作者：
Inzelberg, Rivka [1 ,2 ]
Polyniki, Anna
机构：
[1] Chaim Sheba Med Ctr, Dept Neurol, Sagol Neurosci Ctr, IL-52621 Tel Hashomer, Israel
[2] Tel Aviv Univ, Tel Aviv, Israel
来源：
JOURNAL OF THE NEUROLOGICAL SCIENCES | 2010年 / 289卷 / 1-2期
关键词：
Dementia; Parkinson's disease; Genetic; Parkin; Synuclein; ApoE; RECESSIVE JUVENILE PARKINSONISM; ALPHA-SYNUCLEIN; APOLIPOPROTEIN-E; LEWY BODIES; MUTATIONS; DUPLICATION; ONSET; LRRK2; NEUROPATHOLOGY; HETEROGENEITY;
D O I：
10.1016/j.jns.2009.08.015
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The occurrence of dementia in genetic Parkinson's disease is heterogeneous The onset and progression of diverse forms of familial Parkinson's disease might be different than that of sporadic disease. Since dementia is an age related process, its risk increases with advanced disease severity and duration The onset and progression of dementia is expected to vary between genetic forms, which present at diverse ages with different symptomatologies it seems that genetic Parkinson's disease variants in which Lewy bodies are the prominent pathological hallmark - such as in PARK1, PARK4 and PARK8 - dementia is part of the phenotype On the contrary. in PARK2 which is not accompanied by Lewy body accumulation, patients do not show a systematic cognitive decline. This review presents information on dementia in genetic forms of Parkinson's disease. (C) 2009 Elsevier B V All rights reserved
引用
收藏
页码：23 / 26
页数：4
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