Synthesis of Spongidine A and D and Petrosaspongiolide L Methyl Ester Using Pyridine C-H Functionalization

被引：10

作者：

Bartels, Florian ^{[1
]}

Weber, Manuela ^{[2
]}

Christmann, Mathias ^{[1
]}

机构：

[1] Free Univ Berlin, Inst Chem & Biochem, Takustr 3, D-14195 Berlin, Germany

[2] Free Univ Berlin, Inst Chem & Biochem, Fabeckstr 34-36, D-14195 Berlin, Germany

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 02期

关键词：

FREE-RADICAL REACTIONS; MARINE SPONGE; BULI-ME2N(CH2)(2)OLI; CONSTRUCTION; ALKYLATION; LITHIATION; ALCOHOLS; OLEFINS; ACCESS; FE;

D O I：

10.1021/acs.orglett.9b04315

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient strategy for the synthesis of the potent phospholipase A(2) inhibitors spongidine A and D is presented. The tetracyclic core of the natural products was assembled via an intramolecular hydrogen atom transfer initiated Minisci reaction. A divergent late-stage functionalization of the tetracyclic ring system was also used to achieve a concise synthesis of petrosaspongiolide L methyl ester.

引用

页码：552 / 555

页数：4

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