Chiral Isocyanoazides: Efficient Bifunctional Reagents for Bioconjugation

被引：65

作者：

Nenajdenko, Valentine G. ^{[1
]}

Gulevich, Anton V. ^{[1
]}

Sokolova, Nadezhda V. ^{[1
]}

Mironov, Andrey V. ^{[1
]}

Balenkova, Elizabeth S. ^{[1
]}

机构：

[1] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 199991, Russia

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 2010卷 / 08期

关键词：

Isocyanides; Azides; Multicomponent reactions; Click chemistry; Bioconjugation; MULTICOMPONENT REACTIONS; HUISGEN CYCLOADDITION; CLICK CHEMISTRY; ORGANIC AZIDES; AMINO-ACIDS; 1,2,3-TRIAZOLES; COORDINATION; LIGATION; ALKYNES;

D O I：

10.1002/ejoc.200901326

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral scaffolds combining isocyanide and azide groups can be effectively synthesized to permit the efficient construction of both amino (hydroxy) acids and triazole derivatives, which enables the preparation of hybrid peptide molecules by Ugi/click or click/Ugi strategies.

引用

页码：1445 / 1449

页数：5

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