Novel Diagnostics and Therapeutics in Sepsis

被引：16

作者：

Leong, Kieran ^{[1
]}

Gaglani, Bhavita ^{[2
]}

Khanna, Ashish K. ^{[2
,3
]}

McCurdy, Michael T. ^{[1
]}

机构：

[1] Univ Maryland, Sch Med, Div Pulm & Crit Care, Baltimore, MD 21201 USA

[2] Wake Forest Univ Hosp, Sect Crit Care Med, Dept Anesthesiol, Winston Salem, NC 27157 USA

[3] Outcomes Res Consortium, Dept Outcomes Res, Cleveland, OH 44195 USA

来源：

BIOMEDICINES | 2021年 / 9卷 / 03期

关键词：

sepsis; novel; diagnosis; diagnostics; therapy; therapeutic; treatment; management; biomarkers; innovation; C-REACTIVE PROTEIN; INTERNATIONAL CONSENSUS DEFINITIONS; MONOCYTE CHEMOATTRACTANT PROTEIN-1; DESORPTION IONIZATION-TIME; CELL-DERIVED MICROVESICLES; FLIGHT MASS-SPECTROMETRY; SEPTIC SHOCK; INTENSIVE-CARE; ANGIOTENSIN-II; ORGAN FAILURE;

D O I：

10.3390/biomedicines9030311

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sepsis management demands early diagnosis and timely treatment that includes source control, antimicrobial therapy, and resuscitation. Currently employed diagnostic tools are ill-equipped to rapidly diagnose sepsis and isolate the offending pathogen, which limits the ability to offer targeted and lowest-toxicity treatment. Cutting edge diagnostics and therapeutics in development may improve time to diagnosis and address two broad management principles: (1) source control by removing the molecular infectious stimulus of sepsis, and (2) attenuation of the pathological immune response allowing the body to heal. This review addresses novel diagnostics and therapeutics and their role in the management of sepsis.

引用

页数：23

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