Acute intermittent porphyria associated with ovarian stimulation - A case report

BACKGROUND: Induction of ovulation in the course of infertility treatment is increasingly commonplace in the 21st century. As a consequence, it can be expected that previously unrecognized complications of the procedure will be reported. CASE: A 36-year-old woman presented with severe pelvic pain and hyponatremia after ovarian stimulation with gonadotropins. After admission with a presumptive diagnosis of ovarian hyperstimulation syndrome, a further family history revealed acute intermittent porphyria. A 24-hour urine collection confirmed the diagnosis. CONCLUSION. Hormonal therapy for induction of ovulation in the course of infertility treatment may precipitate attacks of acute intermittent porphyria. A careful history must be undertaken prior to administration of such hormonal preparations.