A double-edged sword: The role of NKT cells in malaria and HIV infection and immunity

被引：22

作者：

Vasan, Sandhya ^{[1
,2
]}

Tsuji, Moriya ^{[1
]}

机构：

[1] Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

[2] Rockefeller Univ, New York, NY 10065 USA

来源：

SEMINARS IN IMMUNOLOGY | 2010年 / 22卷 / 02期

关键词：

NKT cell; Glycolipid; CD1d; HIV; Malaria; Vaccine; Adjuvant; KILLER T-CELLS; LIGAND ALPHA-GALACTOSYLCERAMIDE; IMMUNODEFICIENCY-VIRUS-INFECTION; MURINE CEREBRAL MALARIA; DENDRITIC CELLS; PROTECTIVE IMMUNITY; IN-VIVO; PHASE-I; ANTIBODY-RESPONSES; INNATE IMMUNITY;

D O I：

10.1016/j.smim.2009.11.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

NKT cells are known to play a role against certain microbial infections, including malaria and HIV, two major global infectious diseases. NKT cells exhibit either protective or pathogenic role against malaria. They are depleted by HIV infection and have a direct pathogenic role against many opportunistic infections common in end-stage AIDS. This review discusses the various features of the interaction between NKT cells and malaria parasites and HIV, and the potential to harness this interaction for therapeutic and vaccine strategies. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：87 / 96

页数：10

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