The role of CD40 and CD154/CD40L in dendritic cells

被引：330
作者：
Ma, Daphne Y. [1 ]
Clark, Edward A. [1 ]
机构：
[1] Univ Washington, Dept Immunol, Seattle, WA 98195 USA
来源：
SEMINARS IN IMMUNOLOGY | 2009年 / 21卷 / 05期
关键词：
CD40; CD40L; CD154; Dendritic cells; NF-KAPPA-B; TUMOR-NECROSIS-FACTOR; CD40-INDUCED GENE-EXPRESSION; X-LINKED IMMUNODEFICIENCY; ACTIVATED PROTEIN-KINASE; TNF FAMILY-MEMBER; T-CELL; FACTOR RECEPTOR; IMMUNE-RESPONSES; CD40/CD154; INTERACTIONS;
D O I：
10.1016/j.smim.2009.05.010
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In this review, we focus on the function of CD40-CD40L (CD154) interactions in the regulation of dendritic cell (DC)-T cell and DC-B cell crosstalk. In addition, we examine differences and similarities between the CD40 signaling pathway in DCs and other innate immune cell receptors, and how these pathways integrate DC functions. As research into DC vaccines and immunotherapies progresses, further understanding of CD40 and DC function will advance the applicability of DCs in immunotherapy for human diseases. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：265 / 272
页数：8
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