Number needed to treat: A primer for neurointerventionalists

被引：17

作者：

Martinez-Gutierrez, Juan Carlos ^{[1
]}

Leslie-Mazwi, Thabele ^{[2
]}

Chandra, Ronil, V ^{[3
]}

Ong, Kevin L. ^{[4
]}

Nogueira, Raul G. ^{[5
]}

Goyal, Mayank ^{[6
]}

Albuquerque, Felipe C. ^{[7
]}

Hirsch, Joshua A. ^{[8
]}

机构：

[1] Brigham & Womens Hosp, Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA

[2] Harvard Med Sch, Massachusetts Gen Hosp, Neuroendovasc Program, Boston, MA 02115 USA

[3] Monash Univ, Monash Hlth, Monash Imaging, Neurointervent Radiol, Melbourne, Vic, Australia

[4] Exponent Inc, Philadelphia, PA USA

[5] Emory Univ, Marcus Stroke & Neurosci Ctr, Grady Mem Hosp, Neuroendovasc Serv,Sch Med, Atlanta, GA USA

[6] Foothills Med Ctr, Seaman Family MR Res Ctr, Diagnost & Intervent Neuroradiol, Calgary, AB, Canada

[7] Barrow Neurol Inst, Endovasc Neurosurg, Phoenix, AZ 85013 USA

[8] Harvard Med Sch, Massachusetts Gen Hosp, Neurointervent Radiol, Boston, MA 02115 USA

来源：

INTERVENTIONAL NEURORADIOLOGY | 2019年 / 25卷 / 06期

关键词：

Interventional neuroradiology; statistics; stroke; TISSUE-PLASMINOGEN ACTIVATOR; MIDDLE CEREBRAL-ARTERY; ACUTE ISCHEMIC-STROKE; THROMBOLYTIC THERAPY; ENDOVASCULAR THERAPY; ENTIRE RANGE; THROMBECTOMY; TRIAL; INFARCTION; ASPIRIN;

D O I：

10.1177/1591019919858733

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: The number needed to treat is a commonly used statistical term in modern neurointerventional practice. It represents the number of patients that need to be treated for one patient to benefit from an intervention. Given its growing popularity in reflecting study results, understanding the basics behind this statistic is of practical value to the neurointerventionalist. Methods: Here, we review the basic theory and calculation of the number needed to treat, its application to stroke interventions, and its limitations. In addition, we demonstrate several simple methods of calculating the number needed to treat utilizing recent thrombectomy trial results. By presenting the number needed to treat as a universal metric, we provide a comprehensive comparative of the number needed to treat for key stroke therapies, including mechanical thrombectomy, tissue plasminogen activator, carotid endarterectomy, and prevention with antiplatelet and statin drugs. Conclusions: In comparison with available stroke therapies, mechanical thrombectomy stands out as the most effective acute intervention in patients with emergent large-vessel occlusions. Understanding how the number needed to treat is derived and its implications helps provide perspective to clinical trial data, identify health-care resource priorities, and improve communication with patients, health-care providers, and additional key stakeholders.

引用

页码：613 / 618

页数：6

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