18F-2-fluoro-2-deoxy-D-glucose-positron emission tomography metabolic pattern assessment in the brain of betel quid dependent individuals

被引：1

作者：

Yuan, Fulai ^{[1
]}

Yu, Jie ^{[2
]}

Liao, Guang ^{[2
]}

Li, Jian ^{[2
]}

Long, Tingting ^{[2
]}

Li, Yulai ^{[2
]}

Chen, Dengming ^{[2
]}

Dai, Qionghai ^{[3
]}

Zhu, Xueling ^{[4
]}

Hu, Shuo ^{[2
,5
,6
]}

Qian, Zhaoxin ^{[7
]}

机构：

[1] Cent South Univ, Xiangya Hosp, Hlth Management Ctr, Changsha, Peoples R China

[2] Cent South Univ, XiangYa Hosp, Dept Nucl Med, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China

[3] Tsinghua Univ, Dept Automat, Tsinghua Natl Lab Informat Sci & Technol, Beijing, Peoples R China

[4] Cent South Univ, Xiangya Hosp, Dept Radiol, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China

[5] Natl Hlth Commiss, Key Lab Biol Nanotechnol, Changsha, Peoples R China

[6] Natl Clin Res Ctr Geriatr Dis XIANGYA, Changsha, Peoples R China

[7] Cent South Univ, XiangYa Hosp, Dept Emergency, Changsha, Peoples R China

来源：

ADDICTION BIOLOGY | 2021年 / 26卷 / 05期

基金：

中国国家自然科学基金;

关键词：

F-18‐ FDG‐ PET; addiction; betel quid; betel quid dependence; brain metabolism;

D O I：

10.1111/adb.13043

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The primary objective of this study was to identify the metabolic pattern in the brains of betel quid dependent (BQD) individuals using F-18-2-fluoro-2-deoxy-D-glucose-positron emission tomography (F-18-FDG-PET). A total of 42 individuals (16 BQD individuals and 26 healthy controls, HCs) enrolled at the Department of Nuclear Medicine of Xiangya Hospital underwent brain F-18-FDG-PET. Group comparisons using statistical parametric mapping (SPM) were performed to identify the F-18-FDG-PET patterns. Standardized uptake value ratios of anterior cingulate, frontal, thalamus, parietal, occipital, temporal and cerebellum were calculated by SPM. The characteristics of abnormal metabolism in brain regions were quantified using the xjView toolbox, and a 3-D brain map was drawn using BrainNet Viewer. We found significant metabolic reduction in the bilateral middle prefrontal cortex (PFC) and the left orbital frontal gyrus (OFC). In contrast, hypermetabolism was observed in the inferior cerebellum, fusiform, superior cerebellum, parahippocampal, vermis, lingual and thalamus. However, we found no significant difference between the BQD and HC group in the anterior cingulate, thalamus, cerebellum and frontal, temporal, parietal and occipital lobes. In summary, we found abnormal F-18-FDG-PET metabolic pattern in BQD individuals, and this pattern may help the treatment of BQD.

引用

页数：9

共 53 条

[1] Cerebellar vermis involvement in cocaine-related behaviors [J].

Anderson, Carl M. ;

Maas, Luis C. ;

Frederick, Blaise deB. ;

Bendor, Jacob T. ;

Spencer, Thomas J. ;

Livni, Eli ;

Lukas, Scott E. ;

Fischman, Alan J. ;

Madras, Bertha K. ;

Renshaw, Perry F. ;

Kaufman, Marc J. .

NEUROPSYCHOPHARMACOLOGY, 2006, 31 (06) :1318-1326

[2] Neural systems and cue-induced cocaine craving [J].

Bonson, KR ;

Grant, SJ ;

Contoreggi, CS ;

Links, JM ;

Metcalfe, J ;

Weyl, HL ;

Kurian, V ;

Ernst, M ;

London, ED .

NEUROPSYCHOPHARMACOLOGY, 2002, 26 (03) :376-386

[3]

Chen F, 2015, AM J TRANSL RES, V7, P364

[4] Self-related neural response to tailored smoking-cessation messages predicts quitting [J].

Chua, Hannah Faye ;

Ho, S. Shaun ;

Jasinska, Agnes J. ;

Polk, Thad A. ;

Welsh, Robert C. ;

Liberzon, Israel ;

Strecher, Victor J. .

NATURE NEUROSCIENCE, 2011, 14 (04) :426-427

[5] Altered functional connectivity of the insular cortex across prefrontal networks in cocaine addiction [J].

Cisler, Josh M. ;

Elton, Amanda ;

Kennedy, Ashley P. ;

Young, Jonathan ;

Smitherman, Sonet ;

James, George Andrew ;

Kilts, Clinton D. .

PSYCHIATRY RESEARCH-NEUROIMAGING, 2013, 213 (01) :39-46

[6] Prediction and preparation, fundamental functions of the cerebellum [J].

Courchesne, E ;

Allen, G .

LEARNING & MEMORY, 1997, 4 (01) :1-35

[7] Reorganization and plasticity in the adult brain during learning of motor skills [J].

Doyon, J ;

Benali, H .

CURRENT OPINION IN NEUROBIOLOGY, 2005, 15 (02) :161-167

[8]

Fein G, 2002, ALCOHOL CLIN EXP RES, V26, P558, DOI 10.1097/00000374-200204000-00017

[9] The effect of practice on a sustained attention task in cocaine abusers [J].

Goldstein, Rita Z. ;

Tomasi, Dardo ;

Alia-Klein, Nelly ;

Zhang, Lei ;

Telang, Frank ;

Volkow, Nora D. .

NEUROIMAGE, 2007, 35 (01) :194-206

[10] Functional connectivity in the resting brain: A network analysis of the default mode hypothesis [J].

Greicius, MD ;

Krasnow, B ;

Reiss, AL ;

Menon, V .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (01) :253-258

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