Trends in asymmetric Michael reactions catalysed by tripeptides in combination with an achiral additive in different solvents

被引：75

作者：

Tsogoeva, SB

Jagtap, SB

Ardemasova, ZA

Kalikhevich, VN

机构：

[1] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany

[2] St Petersburg State Univ, Dept Chem, Nat Prod Chem Chair, St Petersburg 198504, Russia

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2004年 / 2004卷 / 19期

关键词：

asymmetric catalysis; Michael addition; organocatalyst; peptides;

D O I：

10.1002/ejoc.200400243

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The potential of tripeptides 3, 6 and 12 as chiral catalysts for asymmetric Michael addition reactions in the presence of an achiral additive has been tested in different solvents (CHCl3, acetone, DMF, DMSO and the room-temperature ionic liquid [bmim]PF6). The dependence of yields and enantiomeric excesses on the solvent used has been demonstrated. The experiments show that the combination of additive and peptides provides a catalytic system that appears to be better than the sum of its parts.

引用

页码：4014 / 4019

页数：6

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