Regulation of Ce (III)/Ce (IV) ratio of cerium oxide for antibacterial application

被引：35

作者：

Zhang, Haifeng ^{[1
,3
]}

Qiu, Jiajun ^{[1
]}

Yan, Bangcheng ^{[1
,3
]}

Liu, Lidan ^{[1
,3
]}

Chen, Dafu ^{[2
]}

Liu, Xuanyong ^{[1
,3
,4
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

[2] Beijing JiShuiTan Hosp, Beijing Res Inst Orthopaed & Traumatol, Lab Bone Tissue Engn, Beijing Lab Biomed Mat, Beijing 100035, Peoples R China

[3] Univ Chinese Acad Sci, Ctr Mat Sci & Optoelect Engn, Beijing 100049, Peoples R China

[4] Univ Chinese Acad Sci, Sch Chem & Mat Sci, Hangzhou Inst Adv Study, Hangzhou 310024, Peoples R China

来源：

ISCIENCE | 2021年 / 24卷 / 03期

基金：

中国国家自然科学基金;

关键词：

NANOPARTICLES; NANOCERIA; TOXICITY;

D O I：

10.1016/j.isci.2021.102226

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Antibiotics have been considered as effective weapons against bacterial infections since they were discovered. However, antibiotic resistance caused by overuse and abuse of antibiotics is an emerging public health threat nowadays. Fully defeating bacterial infections has become a tough challenge. In this work, cerium oxide was fabricated on medical titanium by thermolysis of cerium-containing metal-organic framework (Ce-BTC). Regulation of Ce (III)/Ce (IV) ratios was realized by pyrolysis of Ce-BTC in different gas environment, and the antibacterial properties were studied. The results indicated that, in acidic conditions, ceria with a high Ce (III)/Ce (IV) ratio owned high oxidase-like activity which could produce reactive oxygen species. Moreover, ceria with high Ce (III) content possessed strong ATP deprivation capacity which could cut off the energy supply of bacteria. Based on this, ceria with a high Ce (III)/Ce (IV) ratio exhibited superior antibacterial activity

引用

页数：22

共 35 条

[1] TiO2@CeOx Core-Shell Nanoparticles as Artificial Enzymes with Peroxidase-Like Activity [J].