Inositol 1,4,5-trisphosphate and cyclic ADP-ribose mobilize Ca2+ in a protist, Euglena gracilis

被引：19

作者：

Masuda, W

Takenaka, S

Tsuyama, S

Tokunaga, M

Yamaji, R

Inui, H

Miyatake, K

Nakano, Y

机构：

[1] Hagoromo Gakuen Coll, Lab Nutr & Food Sci, Osaka 592, Japan

[2] Univ Osaka Prefecture, Dept Vet Sci, Osaka 593, Japan

[3] Kagoshima Univ, Dept Biochem Sci & Technol, Kagoshima 890, Japan

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1997年 / 118卷 / 03期

关键词：

Ca2+ mobilization; cyclic ADP-ribose; inositol 1,4,5-trisphosphate; caffeine; thimerosal; inositol 1,4,5-trisphosphate-induced Ca2+ release; Ca2+-induced Ca2+ release; cell cycle regulation; Euglena gracilis;

D O I：

10.1016/S0742-8413(97)00173-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inositol 1,4,5-trisphosphate (InsP(3)) and cyclic ADP-ribose (cADPR) released Ca2+ from microsome fraction prepared from Euglena gracilis in dose-dependent manners. Caffeine, which also induced Ca2+ release from the microsomes, caused desensitization of the Ca2+ response to cADPR, although the Ca2+ response to InsP(3) was not affected by caffeine. Further, ruthenium red inhibited the Ca2+ release induced by cADPR, but not by InsP(3). These results suggest that cADPR functions as an endogenous messenger to activate a caffeine-sensitive, Ca2+-release mechanism, whereas InsP(3) induces Ca2+ release by a distinct mechanism in E. gracilis. (C) 1997 Elsevier Science Inc.

引用

页码：279 / 283

页数：5

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