Tumor microenvironment for cancer stem cells

被引：118

作者：

Kise, Kazuyoshi ^{[1
]}

Kinugasa-Katayama, Yumi ^{[1
,2
]}

Takakura, Nobuyuki ^{[1
]}

机构：

[1] Osaka Univ, Microbial Dis Res Inst, Dept Signal Transduct, 3-1 Yamada Oka, Suita, Osaka 5650871, Japan

[2] Natl Cerebral & Cardiovasc Ctr, Dept Mol Physiol, 5-7-1 Fujishiro Dai, Suita, Osaka 5658565, Japan

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2016年 / 99卷

关键词：

Cancer stem cells; Niche; Tumor microenvironment; Endothelial cells; Myofibroblasts; Macrophages; ACUTE MYELOID-LEUKEMIA; NF-KAPPA-B; HEMATOPOIETIC STEM; INITIATING CELLS; PROGENITOR CELLS; DRUG-RESISTANCE; NICHE; DIFFERENTIATION; IDENTIFICATION; GLIOBLASTOMA;

D O I：

10.1016/j.addr.2015.08.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Tumor tissues consist of heterogeneous cancer cells including cancer stem cells (CSCs) that can terminally differentiate into cancer cells. Tissue-specific stem cells in normal organs maintain their stemness in a specific microenvironment, the stem cell niche; several studies have suggested that there are specific microenvironments that maintain CSCs in an immature phenotype. Cell types in a CSC niche vary from fibroblasts, to endothelial cells, immune cells, and so on; these non-cancer cells have been suggested to change their original features in the normal tissue/organ and to acquire a phenotype that protects CSCs from anticancer therapies. Therefore, to kill CSCs, we need to understand the cellular and molecular mechanisms involved in the maintenance of the immature phenotype of CSCs and in drug resistance. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：197 / 205

页数：9

共 93 条

[1] PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2 [J].

Aikawa, Yukiko ;

Katsumoto, Takuo ;

Zhang, Pu ;

Shima, Haruko ;

Shino, Mika ;

Terui, Kiminori ;

Ito, Etsuro ;

Ohno, Hiroaki ;

Stanley, E. Richard ;

Singh, Harinder ;

Tenen, Daniel G. ;

Kitabayashi, Issay .

NATURE MEDICINE, 2010, 16 (05) :580-U115

[2] Prospective identification of tumorigenic breast cancer cells [J].

Al-Hajj, M ;

Wicha, MS ;

Benito-Hernandez, A ;

Morrison, SJ ;

Clarke, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3983-3988

[3] Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche [J].

Arai, F ;

Hirao, A ;

Ohmura, M ;

Sato, H ;

Matsuoka, S ;

Takubo, K ;

Ito, K ;

Koh, GY ;

Suda, T .

CELL, 2004, 118 (02) :149-161

[4] A meta-analysis of human embryonic stem cells transcriptome integrated into a web-based expression atlas [J].

Assou, Said ;

Le Carrour, Tanguy ;

Tondeur, Sylvie ;

Strom, Susanne ;

Gabelle, Audrey ;

Marty, Sophie ;

Nadal, Laure ;

Pantesco, Veronique ;

Reme, Thierry ;

Hugnot, Jean-Philippe ;

Gasca, Stephan ;

Hovatta, Outi ;

Hamamah, Samir ;

Klein, Bernard ;

De Vos, John .

STEM CELLS, 2007, 25 (04) :961-973

[5] Inflammation and cancer: back to Virchow? [J].

Balkwill, F ;

Mantovani, A .

LANCET, 2001, 357 (9255) :539-545

[6] Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro [J].

Barker, Nick ;

Huch, Meritxell ;

Kujala, Pekka ;

van de Wetering, Marc ;

Snippert, Hugo J. ;

van Es, Johan H. ;

Sato, Toshiro ;

Stange, Daniel E. ;

Begthel, Harry ;

van den Born, Maaike ;

Danenberg, Esther ;

van den Brink, Stieneke ;

Korving, Jeroen ;

Abo, Arie ;

Peters, Peter J. ;

Wright, Nick ;

Poulsom, Richard ;

Clevers, Hans .

CELL STEM CELL, 2010, 6 (01) :25-36

[7] Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor Regulates Myeloid Inflammation and T Cell Immunity in Pancreatic Cancer [J].

Bayne, Lauren J. ;

Beatty, Gregory L. ;

Jhala, Nirag ;

Clark, Carolyn E. ;

Rhim, Andrew D. ;

Stanger, Ben Z. ;

Vonderheide, Robert H. .

CANCER CELL, 2012, 21 (06) :822-835

[8] A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours [J].

Beck, Benjamin ;

Driessens, Gregory ;

Goossens, Steven ;

Youssef, Khalil Kass ;

Kuchnio, Anna ;

Caauwe, Amelie ;

Sotiropoulou, Panagiota A. ;

Loges, Sonja ;

Lapouge, Gaelle ;

Candi, Aurelie ;

Mascre, Guilhem ;

Drogat, Benjamin ;

Dekoninck, Sophie ;

Haigh, Jody J. ;

Carmeliet, Peter ;

Blanpain, Cedric .

NATURE, 2011, 478 (7369) :399-+

[9] An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors [J].

Ben-Porath, Ittai ;

Thomson, Matthew W. ;

Carey, Vincent J. ;

Ge, Ruping ;

Bell, George W. ;

Regev, Aviv ;

Weinberg, Robert A. .

NATURE GENETICS, 2008, 40 (05) :499-507

[10] Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma [J].

Bhat, Krishna P. L. ;

Balasubramaniyan, Veerakumar ;

Vaillant, Brian ;

Ezhilarasan, Ravesanker ;

Hummelink, Karlijn ;

Hollingsworth, Faith ;

Wani, Khalida ;

Heathcock, Lindsey ;

James, Johanna D. ;

Goodman, Lindsey D. ;

Conroy, Siobhan ;

Long, Lihong ;

Lelic, Nina ;

Wang, Suzhen ;

Gumin, Joy ;

Raj, Divya ;

Kodama, Yoshinori ;

Raghunathan, Aditya ;

Olar, Adriana ;

Joshi, Kaushal ;

Pelloski, Christopher E. ;

Heimberger, Amy ;

Kim, Se Hoon ;

Cahill, Daniel P. ;

Rao, Ganesh ;

Den Dunnen, Wilfred F. A. ;

Boddeke, Hendrikus W. G. M. ;

Phillips, Heidi S. ;

Nakano, Ichiro ;

Lang, Frederick F. ;

Colman, Howard ;

Sulman, Erik P. ;

Aldape, Kenneth .

CANCER CELL, 2013, 24 (03) :331-346

← 1 2 3 4 5 6 7 8 9 10 →