Noninvasive monitoring of tissue hemoglobin using UV-VIS diffuse reflectance spectroscopy: a pilot study

被引：42

作者：

Bender, Janelle E. ^{[1
]}

Shang, Allan B. ^{[2
]}

Moretti, Eugene W. ^{[2
]}

Yu, Bing ^{[1
]}

Richards, Lisa M. ^{[1
]}

Ramanujam, Nirmala ^{[1
]}

机构：

[1] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA

[2] Duke Univ, Med Ctr, Dept Anesthesiol, Durham, NC 27710 USA

来源：

OPTICS EXPRESS | 2009年 / 17卷 / 26期

关键词：

OPTICAL-PROPERTIES; BLOOD HEMATOCRIT; INVERSE MODEL;

D O I：

10.1364/OE.17.023396

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We conducted a pilot study on 10 patients undergoing general surgery to test the feasibility of diffuse reflectance spectroscopy in the visible wavelength range as a noninvasive monitoring tool for blood loss during surgery. Ratios of raw diffuse reflectance at wavelength pairs were tested as a first-pass for estimating hemoglobin concentration. Ratios can be calculated easily and rapidly with limited post-processing, and so this can be considered a near real-time monitoring device. We found the best hemoglobin correlations were when ratios at isosbestic points of oxy- and deoxyhemoglobin were used, specifically 529/500 nm. Baseline subtraction improved correlations, specifically at 520/509 nm. These results demonstrate proof-of-concept for the ability of this noninvasive device to monitor hemoglobin concentration changes due to surgical blood loss. The 529/500 nm ratio also appears to account for variations in probe pressure, as determined from measurements on two volunteers. (C) 2009 Optical Society of America

引用

页码：23396 / 23409

页数：14

共 30 条

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