The path to next generation biofuels: successes and challenges in the era of synthetic biology

被引:123
作者
Dellomonaco, Clementina [1 ]
Fava, Fabio [2 ]
Gonzalez, Ramon [1 ,3 ]
机构
[1] Rice Univ, Dept Chem & Biomol Engn, Houston, TX 77251 USA
[2] Univ Bologna, Dept Appl Chem & Mat Sci, I-40126 Bologna, Italy
[3] Rice Univ, Dept Bioengn, Houston, TX USA
基金
美国国家科学基金会;
关键词
RECOMBINANT SACCHAROMYCES-CEREVISIAE; CLOSTRIDIUM-ACETOBUTYLICUM ATCC-824; FUEL ETHANOL-PRODUCTION; INCREASED SOLVENT PRODUCTION; ESCHERICHIA-COLI; PICHIA-STIPITIS; ANAEROBIC FERMENTATION; XYLOSE FERMENTATION; DIRECTED EVOLUTION; BUTANOL PRODUCTION;
D O I
10.1186/1475-2859-9-3
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Volatility of oil prices along with major concerns about climate change, oil supply security and depleting reserves have sparked renewed interest in the production of fuels from renewable resources. Recent advances in synthetic biology provide new tools for metabolic engineers to direct their strategies and construct optimal biocatalysts for the sustainable production of biofuels. Metabolic engineering and synthetic biology efforts entailing the engineering of native and de novo pathways for conversion of biomass constituents to short-chain alcohols and advanced biofuels are herewith reviewed. In the foreseeable future, formal integration of functional genomics and systems biology with synthetic biology and metabolic engineering will undoubtedly support the discovery, characterization, and engineering of new metabolic routes and more efficient microbial systems for the production of biofuels.
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页数:15
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