Perforin, CD28 and CD95 expression in circulating CD4 and CD8 cells as predictors of head and neck (H&N) cancer patient survival

被引：5

作者：

Laytragoon-Lewin, Nongnit ^{[1
]}

Jonson, Fredrik ^{[2
]}

Lundgren, Jan ^{[3
]}

Rutqvist, Lars Erik ^{[4
]}

Wikby, Anders ^{[5
]}

Lofgren, Sture ^{[1
]}

Lewin, Freddi ^{[6
]}

机构：

[1] Ryhov Hosp, Dept Lab Med, SE-55185 Jonkoping, Sweden

[2] Ryhov Hosp, Dept ENT, SE-55185 Jonkoping, Sweden

[3] Karolinska Univ Hosp, Dept ENT, Stockholm, Sweden

[4] Swedish Match AB, Stockholm, Sweden

[5] Jonkoping Univ, Sch Hlth Sci, Jonkoping, Sweden

[6] Ryhov Hosp, Dept Oncol, SE-55185 Jonkoping, Sweden

来源：

MEDICAL ONCOLOGY | 2014年 / 31卷 / 12期

关键词：

Perforin; CD28; CD95; Circulating T cells; Survival time H&N cancer patients; REGULATORY T-CELLS; FAS LIGAND; MEDIATED CYTOTOXICITY; FOXP3; EXPRESSION; EFFECTOR-CELLS; TOBACCO; APOPTOSIS; SMOKING; LYMPHOCYTES; CARCINOMA;

D O I：

10.1007/s12032-014-0290-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Long-term survival of H&N cancer patients has not improved significantly over the last 30 years. The possibility of using circulating blood cell phenotypes as a prognostic biomarker of H&N cancer patient was investigated in this study. Pre-treatment, circulating T lymphocyte subpopulations as well as the survival time of the patients in question were studied. Upregulated CD4+ perforin+ and CD8+ CD95+ but downregulated CD4+ CD28+ (p < 0.001) were detected in H&N cancer patients. With 3 years of follow-up time, an increase in the frequency of the pre-treatment, circulating CD4+ perforin+ cells and CD8+ perforin+ cells was showed to have reverse effects on the survival time in H&N cancer patients (p < 0.01). Detection of perforin? frequency in CD4+ and CD8+ lymphocyte by FACS is fast, simple and cost-effective. A potential role of perforin expression in CD4+ and CD8+ cells as a prognostic biomarker for H&N cancer patient in the clinical setting was suggested.

引用

页码：1 / 5

页数：5

共 33 条

[1] Effects of cigarette smoking on the human urinary proteome [J].

Airoldi, Luisa ;

Magagnotti, Cinzia ;

Iannuzzi, Angela Rita ;

Marelli, Cristina ;

Bagnati, Renzo ;

Pastorelli, Roberta ;

Colombi, Alessandro ;

Santaguida, Stefano ;

Chiabrando, Chiara ;

Schiarea, Silvia ;

Fanelli, Roberto .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 381 (03) :397-402

[2] Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production [J].

Allan, Sarah E. ;

Crome, Sarah Q. ;

Crellin, Natasha K. ;

Passerini, Laura ;

Steiner, Theodore S. ;

Bacchetta, Rosa ;

Roncarolo, Maria G. ;

Levings, Megan K. .

INTERNATIONAL IMMUNOLOGY, 2007, 19 (04) :345-354

[3] Cytolytic CD4 cells: Direct mediators in infectious disease and malignancy [J].

Brown, Deborah M. .

CELLULAR IMMUNOLOGY, 2010, 262 (02) :89-95

[4] Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance [J].

Cao, Xuefang ;

Cai, Sheng F. ;

Fehniger, Todd A. ;

Song, Jiling ;

Collins, Lynne I. ;

Piwnica-Worms, David R. ;

Ley, Timothy J. .

IMMUNITY, 2007, 27 (04) :635-646

[5] The Combined Effects of Single-Nucleotide Polymorphisms, Tobacco Products, and Ethanol on Normal Resting Blood Mononuclear Cells [J].

Cederblad, Lena ;

Thunberg, Ulf ;

Engstrom, Mats ;

Castro, Juan ;

Rutqvist, Lars Erik ;

Laytragoon-Lewin, Nongnit .

NICOTINE & TOBACCO RESEARCH, 2013, 15 (05) :890-895

[6] Clinical Significance of Regulatory T Cells and CD8+ Effector Populations in Patients With Human Endometrial Carcinoma [J].

Chang, Wen Chun ;

Li, Chao-Hsu ;

Huang, Su Cheng ;

Chang, Daw-Yuan ;

Chou, Li-Yun ;

Sheu, Bor-Ching .

CANCER, 2010, 116 (24) :5777-5788

[7] Longitudinal study of smoking patterns in relation to the development of smoking-related secondary primary tumors in patients with upper aerodigestive tract malignancies [J].

Do, KA ;

Johnson, MM ;

Lee, JJ ;

Wu, XF ;

Dong, Q ;

Hong, WK ;

Khuri, FR ;

Spitz, MR .

CANCER, 2004, 101 (12) :2837-2842

[8] Epigenetic alterations in head and neck cancer: Prevalence, clinical significance, and implications [J].

Fan C.-Y. .

Current Oncology Reports, 2004, 6 (2) :152-161

[9]

Gastman BR, 1999, CANCER RES, V59, P5356

[10]

Gavin MA, 2006, P NATL ACAD SCI USA, V103, P6659, DOI 10.1073/pnas.0509484103

← 1 2 3 4 →