Signaling pathways in Th2 development

被引：187
作者：
Mowen, KA [1 ]
Glimcher, LH [1 ]
机构：
[1] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
来源：
IMMUNOLOGICAL REVIEWS | 2004年 / 202卷
关键词：
D O I：
10.1111/j.0105-2896.2004.00209.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In order for an immune response to be successful, it must be of the appropriate type and magnitude. Intracellular residing pathogens require a cell-mediated immune response, whereas extracellular pathogens evoke a humoral immune response. T-helper (Th) cells orchestrate the immune response and are divided into two subsets, Th1 and Th2 cells. Here, we discuss the mechanisms of Th2 development with a focus on signal transduction pathways that influence Th2 differentiation.
引用
收藏
页码：203 / 222
页数：20
相关论文
共 50 条
  • [31] Preproenkephalin, is a Th2 cytokine but is not required for Th2 differentiation in vitro
    Hook, S
    Camberis, M
    Prout, M
    Konig, M
    Zimmer, A
    Van Heeke, G
    Le Gros, G
    IMMUNOLOGY AND CELL BIOLOGY, 1999, 77 (05) : 385 - 390
  • [32] Role and development of Th1/Th2 immune responses in the lungs
    Herring, AC
    Hernández, Y
    Huffnagle, GB
    Toews, GB
    SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE, 2004, 25 (01) : 3 - 10
  • [33] Effects of aryl hydrocarbon receptor signaling on the modulation of Th1/Th2 balance
    Negishi, T
    Kato, Y
    Ooneda, O
    Mimura, J
    Takada, T
    Mochizuki, H
    Yamamoto, M
    Fujii-Kuriyama, Y
    Furusako, S
    JOURNAL OF IMMUNOLOGY, 2005, 175 (11) : 7348 - 7356
  • [34] Early events of TCR signaling are distinct in human Th1 and Th2 cells
    Hannier, S
    Bitegye, C
    Demotz, S
    JOURNAL OF IMMUNOLOGY, 2002, 169 (04) : 1904 - 1911
  • [35] Development of a TH2 Mediated Mouse Model of Esophageal Eosinophilia
    Masterson, Joanne C.
    McNamee, Eoin N.
    Hosford, Lindsay
    Fillon, Sophie A.
    Rustgi, Anil K.
    Lee, James J.
    Furuta, Glenn
    GASTROENTEROLOGY, 2012, 142 (05) : S117 - S117
  • [36] Transcriptional regulation of basophil development and function in Th2 immunity
    Zhang, Sai
    Henry, Everett
    Siracusa, Mark C.
    Sant'Angelo, Derek B.
    JOURNAL OF IMMUNOLOGY, 2016, 196
  • [37] Interferon-alpha negatively regulates Th2 development
    Huber, Jonathan
    Farrar, J. David
    FASEB JOURNAL, 2008, 22
  • [38] Pollen/TLR4 Innate Immunity Signaling Initiates IL-33/ST2/Th2 Pathways in Allergic Inflammation
    Jin Li
    Lili Zhang
    Xin Chen
    Ding Chen
    Xia Hua
    Fang Bian
    Ruzhi Deng
    Fan Lu
    Zhijie Li
    Stephen C. Pflugfelder
    De-Quan Li
    Scientific Reports, 6
  • [39] Maintenance mechanisms of Th2 cytokine production in memory Th2 cells
    Yamashita, M
    Nakayama, T
    FASEB JOURNAL, 2005, 19 (04) : A22 - A22
  • [40] Pollen/TLR4 Innate Immunity Signaling Initiates IL-33/ST2/Th2 Pathways in Allergic Inflammation
    Li, Jin
    Zhang, Lili
    Chen, Xin
    Chen, Ding
    Hua, Xia
    Bian, Fang
    Deng, Ruzhi
    Lu, Fan
    Li, Zhijie
    Pflugfelder, Stephen C.
    Li, De-Quan
    SCIENTIFIC REPORTS, 2016, 6
12345