Signaling pathways in Th2 development

被引：189
作者：
Mowen, KA [1 ]
Glimcher, LH [1 ]
机构：
[1] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
来源：
IMMUNOLOGICAL REVIEWS | 2004年 / 202卷
关键词：
D O I：
10.1111/j.0105-2896.2004.00209.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In order for an immune response to be successful, it must be of the appropriate type and magnitude. Intracellular residing pathogens require a cell-mediated immune response, whereas extracellular pathogens evoke a humoral immune response. T-helper (Th) cells orchestrate the immune response and are divided into two subsets, Th1 and Th2 cells. Here, we discuss the mechanisms of Th2 development with a focus on signal transduction pathways that influence Th2 differentiation.
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收藏
页码：203 / 222
页数：20
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