Neuronal Cholesterol Esterification by ACAT1 in Alzheimer's Disease

被引：15
作者：
Chang, Ta-Yuan [1 ]
Chang, Catherine C. Y. [1 ]
Bryleva, Elena [1 ]
Rogers, Maximillian A. [1 ]
Murphy, Stephanie R. [1 ]
机构：
[1] Dartmouth Med Sch, Dept Biochem, Hanover, NH 03755 USA
来源：
IUBMB LIFE | 2010年 / 62卷 / 04期
关键词：
cholesterol metabolism; ACAT1; oxysterols; Alzheimer's disease; HUMAN ATHEROSCLEROTIC LESIONS; HAMSTER OVARY CELLS; MAMMALIAN ACYL-COA; A-BETA; MOLECULAR-CLONING; PRECURSOR PROTEIN; NUCLEAR RECEPTORS; LIPID-METABOLISM; MOUSE-BRAIN; HUMAN LIVER;
D O I：
10.1002/iub.305
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cholesterol has been implicated in various neurodegenerative diseases. Here we review the connection between cholesterol and Alzheimer's disease (AD), focusing on a recent study that links neuronal cholesterol esterification with biosynthesis of 24(S)hydroxycholesterol and the fate of human amyloid precursor protein in a mouse model of AD. We also briefly evaluate the potential of ACAT1 as a drug target for AD. (C) 2010 IUBMB IUBMB Life, 62(4): 261-267, 2010
引用
收藏
页码：261 / 267
页数：7
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