Neuronal Cholesterol Esterification by ACAT1 in Alzheimer's Disease

被引：16

作者：

Chang, Ta-Yuan ^{[1
]}

Chang, Catherine C. Y. ^{[1
]}

Bryleva, Elena ^{[1
]}

Rogers, Maximillian A. ^{[1
]}

Murphy, Stephanie R. ^{[1
]}

机构：

[1] Dartmouth Med Sch, Dept Biochem, Hanover, NH 03755 USA

来源：

IUBMB LIFE | 2010年 / 62卷 / 04期

关键词：

cholesterol metabolism; ACAT1; oxysterols; Alzheimer's disease; HUMAN ATHEROSCLEROTIC LESIONS; HAMSTER OVARY CELLS; MAMMALIAN ACYL-COA; A-BETA; MOLECULAR-CLONING; PRECURSOR PROTEIN; NUCLEAR RECEPTORS; LIPID-METABOLISM; MOUSE-BRAIN; HUMAN LIVER;

D O I：

10.1002/iub.305

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cholesterol has been implicated in various neurodegenerative diseases. Here we review the connection between cholesterol and Alzheimer's disease (AD), focusing on a recent study that links neuronal cholesterol esterification with biosynthesis of 24(S)hydroxycholesterol and the fate of human amyloid precursor protein in a mouse model of AD. We also briefly evaluate the potential of ACAT1 as a drug target for AD. (C) 2010 IUBMB IUBMB Life, 62(4): 261-267, 2010

引用

页码：261 / 267

页数：7

共 82 条

[1] Identification of a form of acyl-CoA:cholesterol acyltransferase specific to liver and intestine in nonhuman primates [J].

Anderson, RA ;

Joyce, C ;

Davis, M ;

Reagan, JW ;

Clark, M ;

Shelness, GS ;

Rudel, LL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (41) :26747-26754

[2] Cholesterol as a risk factor for dementia and cognitive decline: A systematic review of prospective studies with meta-analysis [J].

Anstey, Kaarin J. ;

Lipnicki, Darren M. ;

Low, Lee-Fay .

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 2008, 16 (05) :343-354

[3] Nuclear receptors in lipid metabolism: Targeting the heart of dyslipidemia [J].

Beaven, SW ;

Tontonoz, P .

ANNUAL REVIEW OF MEDICINE, 2006, 57 :313-329

[4] Crossing the barrier:: oxysterols as cholesterol transporters and metabolic modulators in the brain [J].

Bjorkhem, I. .

JOURNAL OF INTERNAL MEDICINE, 2006, 260 (06) :493-508

[5] Are side-chain oxidized oxysterols regulators also in vivo? [J].

Bjorkhem, Ingemar .

JOURNAL OF LIPID RESEARCH, 2009, 50 :S213-S218

[6]

Brown AJ, 2000, J BIOL CHEM, V275, P27627

[7] Oxysterols: Sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis [J].

Brown, Andrew J. ;

Jessup, Wendy .

MOLECULAR ASPECTS OF MEDICINE, 2009, 30 (03) :111-122

[8] Differential expression of cholesterol hydroxylases in Alzheimer's disease [J].

Brown, J ;

Theisler, C ;

Silberman, S ;

Magnuson, D ;

Gottardi-Littell, N ;

Lee, JM ;

Yager, D ;

Crowley, J ;

Sambamurti, K ;

Rahman, MM ;

Reiss, AB ;

Eckman, CB ;

Wolozin, B .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (33) :34674-34681

[9]

BRYLEVA EY, P NATL ACAD IN PRESS

[10] Mammalian acyl-CoA: cholesterol acyltransferases [J].

Buhman, KF ;

Accad, M ;

Farese, RV .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2000, 1529 (1-3) :142-154

← 1 2 3 4 5 6 7 8 9 →