5,8-Quinolinedione Scaffold as a Promising Moiety of Bioactive Agents

被引：30

作者：

Kadela-Tomanek, Monika ^{[1
]}

Bebenek, Ewa ^{[1
]}

Chrobak, Elwira ^{[1
]}

Boryczka, Stanislaw ^{[1
]}

机构：

[1] Med Univ Silesia, Fac Pharmaceut Sci Sosnowiec, Dept Organ Chem, 4 Jagiellonska Str, PL-41200 Sosnowiec, Poland

来源：

MOLECULES | 2019年 / 24卷 / 22期

关键词：

5; 8-quinolinedione; streptonigrin; biological activity; NAD[P]H-quinone oxidoreductase; IN-VITRO CYTOTOXICITY; NEUTROPHIL RESPIRATORY BURST; BIOLOGICAL EVALUATION; INHIBITORY-ACTIVITY; CRYSTAL-STRUCTURE; DERIVATIVES; POTENT; STREPTONIGRIN; ANTIFUNGAL; LAVENDAMYCIN;

D O I：

10.3390/molecules24224115

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Natural 5,8-quinolinedione antibiotics exhibit a broad spectrum of activities including anticancer, antibacterial, antifungal, and antimalarial activities. The structure-activity research showed that the 5,8-quinolinedione scaffold is responsible for its biological effect. The subject of this review report is a presentation of the pharmacological activity of synthetic 5,8-quinolinedione compounds containing different groups at C-6 and/or C-7 positions. The relationship between the activity and the mechanism of action is included if these data have been included in the original literature. The review mostly covers the period between 2000 and 2019. Previously published literature data were used to present historical points.

引用

页数：21

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