Fecal Lipid Excretion after Consumption of a Black Tea Polyphenol Containing Beverage-Randomized, Placebo-Controlled, Double-Blind, Crossover Study-

被引:14
作者
Ashigai, Hiroshi [1 ]
Taniguchi, Yoshimasa [2 ]
Suzuki, Mihoko [3 ]
Ikeshima, Emiko [1 ]
Kanaya, Tomoka [1 ]
Zembutsu, Kanako [4 ]
Tomita, Shimpei [4 ]
Miyake, Mika [1 ]
Fukuhara, Ikuo [5 ]
机构
[1] Kirin Brewery Co Ltd, Res Labs Hlth Sci & Food Technol, Tsurumi Ku, 1-17-1 Namamugi, Yokohama, Kanagawa 2308628, Japan
[2] Kirin Brewery Co Ltd, Res Labs Key Technol, Kanazawa Ku, 1-13-5 Fukuura, Yokohama, Kanagawa 2360004, Japan
[3] Kirin Beverage Co Ltd, Res Labs Prod Dev, Tsurumi Ku, 1-17-1 Namamugi, Yokohama, Kanagawa 2308628, Japan
[4] New Drug Res Ctr Inc, 452-1 Toiso, Eniwa, Hokkaido 0611405, Japan
[5] Fukuhara Clin, 3-1-15 Shimamatuhigashimati, Eniwa, Hokkaido 0611351, Japan
关键词
black tea polyphenol; fecal lipid; clinical study; FAT;
D O I
10.1248/bpb.b15-00662
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Obesity is a serious medical condition worldwide. Inhibition of lipid absorption is very important in preventing obesity. In a previous study, we found that postprandial elevation of triacylglycerol was suppressed by the intake of black tea polyphenol (BTP). We also reported that BTP caused lipid excretion into feces in an animal study. The present study is a clinical trial that examined lipid excretion. In this randomized, placebo-controlled, double-blind, crossover study, in the first test period participants were asked to drink either a beverage containing 55 mg BTP or a control beverage without BTP 3 times a day for 10 d. After an 11-d interval, for the second test period, they then drank the alternate test beverage 3 times a day for 10 d. During the test periods, the participants were asked to eat meals standardized according to calorie and fat content. Stool samples were obtained during the last 3 d of each test period for fecal lipid measurements. Total lipid excretion increased from 5.51 +/- 1.73 to 6.87 +/- 1.91 g/3 d after BTP intake in comparison with intake of the control beverage. These results indicated that BTP increased lipid excretion.
引用
收藏
页码:699 / 704
页数:6
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