Receptor-independent induction of apoptosis by synthetic retinoids

被引：0

作者：

Lotan, R ^{[1
]}

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Thorac Head & Neck Med Oncol, Houston, TX 77030 USA

来源：

JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS | 2003年 / 17卷 / 01期

关键词：

retinoids; apoptosis; CD437; death receptors; mitochondria;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Retinoids modulate cell proliferation, differentiation and apoptosis. Many of these effects are mediated by nuclear retinoid receptors. However, studies with certain synthetic retinoids, including some that can activate retinoid receptors, revealed that they affect cell growth and especially apoptosis by mechanisms that are independent of nuclear receptors. This chapter describes the pro-apoptotic effects of the synthetic retinoid CD437 {6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid}, and structurally-related retinoids and summarizes the mechanisms by which they induce apoptosis.

引用

页码：13 / 28

页数：16

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