Enhanced pharmaceutical analysis by CE using dynamic surface coating system

被引：33

作者：

Altria, KD ^{[1
]}

机构：

[1] Pharmaceut Dev Europe, GlaxoSmithKline Res & Dev, Ware SG12 0DP, Herts, England

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2003年 / 31卷 / 03期

关键词：

pharmaceutical analysis; capillary electrophoresis; dynamic surface coating;

D O I：

10.1016/S0731-7085(02)00728-8

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The poor repeatability of migration times in capillary electrophoresis (CE) within an injection sequence and between capillaries can be a difficulty when implementing CE for routine pharmaceutical analysis. The use of a dynamic surface coating has been shown to improve the routine performance of CE. The surface coating generates an appreciable electro-osmotic flow at low pH, which reduces analysis times for basic drugs compared to the low pH buffers typically used in CE. The repeatability of migration times and repeatability of migration times between capillaries was improved. Peak tailing for basic drugs was also reduced which improved peak shapes and peak area integration precision. It is concluded that the dynamic coating system is a positive advance in the routine implementation of CE into pharmaceutical analysis. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：447 / 453

页数：7

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