PET-CT imaging of combined brachial and lumbosacral neurolymphomatosis

被引：44
作者：
Kanter, P
Zeidman, A
Streifler, J
Marmelstein, V
Even-Sapir, E
Metser, U
Stein, GY
Cohen, AM
机构：
[1] Hasharon Hosp, Rabin Med Ctr, Hematol Unit, IL-49372 Petah Tiqwa, Israel
[2] Rabin Med Ctr, Dept Internal Med B, Petah Tiqwa, Israel
[3] Rabin Med Ctr, Neurol Unit, Petah Tiqwa, Israel
[4] Tel Aviv Univ, Sackler Sch Med, Tel Aviv Sourasky Med Ctr, Dept Nucl Med, IL-69978 Tel Aviv, Israel
来源：
EUROPEAN JOURNAL OF HAEMATOLOGY | 2005年 / 74卷 / 01期
关键词：
aggressive lymphoma; neurolymphomatosis; fluorine-18; fluorodeoxyglucose; positron emission tomography; brachial and lumbosacral plexopathy;
D O I：
10.1111/j.1600-0609.2004.00369.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Neurolymphomatosis is a rare manifestation of progressive non-Hodgkin's lymphoma. A 44-yr-old man with diffuse large B-cell lymphoma presented with unilateral progressive peripheral sensorimotor neuropathy after the 7th cycle of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone) therapy. No pathology in the nervous system was evident by computerized tomography (CT), magnetic resonance imaging (MRI) of the head, spinal axis and plexuses and by repeated analysis of cerebrospinal fluid. However, the hybrid modality of positron emission tomography (PET) of fluorinated deoxyglucose (FDG) combined with CT scan (PET-CT) showed unilateral involvement of both the brachial and lumbosacral nervous plexuses. A complete recovery of neurological manifestations and normalization of PET-CT followed intensive chemotherapy with autologous stem cell transplantation. The diagnosis and localization of neurolymphomatosis may be supported by PET-CT imaging.
引用
收藏
页码：66 / 69
页数：4
相关论文
共 25 条
[1]  
Baehring JM, 2003, NEURO-ONCOLOGY, V5, P104
[2]  
Beyer T, 2000, J NUCL MED, V41, P1369
[3]   NEUROLYMPHOMATOSIS - A CLINICOPATHOLOGICAL SYNDROME REEMERGES [J].
DIAZARRASTIA, R ;
YOUNGER, DS ;
HAIR, L ;
INGHIRAMI, G ;
HAYS, AP ;
KNOWLES, DM ;
ODEL, JG ;
FETELL, MR ;
LOVELACE, RE ;
ROWLAND, LP .
NEUROLOGY, 1992, 42 (06) :1136-1141
[4]   Nonmyeloablative allogeneic hematopoietic transplantation:: A promising salvage therapy for patients with non-Hodgkin's lymphoma whose disease has failed a prior autologous transplantation [J].
Escalón, MP ;
Champlin, RE ;
Saliba, RM ;
Acholonu, SA ;
Hosing, C ;
Fayad, L ;
Giralt, S ;
Ueno, T ;
Maadani, F ;
Pro, B ;
Donato, M ;
McLaughlin, P ;
Khouri, IF .
JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (12) :2419-2423
[5]   Overview of non-Hodgkin's lymphoma: Biology, staging, and treatment [J].
Fisher, RI .
SEMINARS IN ONCOLOGY, 2003, 30 (02) :3-9
[6]   FDG-PET/CT in re-staging of patients with lymphoma [J].
Freudenberg, LS ;
Antoch, G ;
Schütt, P ;
Beyer, T ;
Jentzen, W ;
Müller, SP ;
Görges, R ;
Nowrousian, MR ;
Bockisch, A ;
Debatin, JF .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2004, 31 (03) :325-329
[7]   High-dose intravenous methotrexate followed by autologous stem cell transplantation as a potentially effective therapy for neurolymphomatosis [J].
Ghobrial, IM ;
Buadi, F ;
Spinner, RJ ;
Colgan, JP ;
Wolanskyj, AP ;
Dyck, PJ ;
Witzig, TE ;
Micallef, IN ;
O'Neill, BP .
CANCER, 2004, 100 (11) :2403-2407
[8]   Non-Hodgkin lymphoma: an update [J].
Hennessy, BT ;
Hanrahan, E ;
Daly, PA .
LANCET ONCOLOGY, 2004, 5 (06) :341-353
[9]  
HUGHES RAC, 1994, J ROY SOC MED, V87, P526
[10]   Fluorine-18 fluorodeoxyglucose positron emission tomography in the staging and follow-up of lymphoma: is it time to shift gears? [J].
Kostakoglu, L ;
Goldsmith, SJ .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 2000, 27 (10) :1564-1578
123