Effective Desensitization to Tocilizumab in Delayed Hypersensitivity Reaction

被引：8

作者：

Cortellini, Gabriele ^{[1
]}

Mascella, Fabio ^{[1
]}

Simoncelli, Margherita ^{[1
]}

Lippolis, Domenico ^{[1
]}

Focherini, Maria Cristina ^{[1
]}

Cortellini, Fabio ^{[1
]}

Cherubini, Chiara ^{[2
]}

Gavioli, Barbara ^{[2
]}

Ballardini, Giorgio ^{[1
]}

机构：

[1] Azienda Sanit Romagna, Internal Med, Allergy Unit, Rimini Hosp, Rimini, Italy

[2] Azienda Sanit Romagna, Pharm Unit, Rimini Hosp, Rimini, Italy

来源：

PHARMACOLOGY | 2018年 / 102卷 / 1-2期

关键词：

Tocilizumab; Desensitization; Delayed hypersensitivity; BIOLOGIC AGENTS; DISEASE; DIAGNOSIS;

D O I：

10.1159/000490419

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We present tocilizumab desensitization of a 47-year-old woman affected by rheumatoid arthritis with full body delayed erythematous urticarial reaction. Skin test for tocilizumab gave cutaneous reaction after 6 h at 20 mg/mL. The schedule of desensitization was then adapted for non-immediate reaction. We prepared a desensitization procedure reaching the cumulative dose of 516 mg in 5 weeks. After 6 months, the repetition of skin tests had a negative result, with demonstration of tolerance induction. Today the patient has good control of the disease. (C) 2018 S. Karger AG, Basel

引用

页码：114 / 116

页数：3

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