PADI4 and tumourigenesis

被引：49

作者：

Chang, Xiaotian ^{[1
]}

Fang, Kehua ^{[1
]}

机构：

[1] Shandong Acad Med Sci, Med Biotechnol Res Ctr, Prov Lab Modern Med & Technol Shandong, Minist Hlth,Lab Biodrugs, Jinan 250062, Shandong, Peoples R China

来源：

CANCER CELL INTERNATIONAL | 2010年 / 10卷

关键词：

CD34-POSITIVE STROMAL CELLS; P53 TARGET GENES; PEPTIDYLARGININE-DEIMINASE; RHEUMATOID-ARTHRITIS; EXPRESSION ANALYSIS; MOLECULAR-CLONING; CDNA CLONING; CITRULLINATION; LOCALIZATION; ORGANIZATION;

D O I：

10.1186/1475-2867-10-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

PADI4 post-translationally converts peptidylarginine to citrulline, a process called citrullination. Studies have demonstrated the high expression of PADI4 in various malignant tumour tissues. PADI4 is also expressed at high levels in the blood of patients with some malignant tumours. Thus far, citrullination of histone, cytokeratin, antithrombin and fibronectin have been confirmed to be involved in abnormal apoptosis, high coagulation, and disordered cell proliferation and differentiation, all of which are main features of malignant tumours. PADI4 is expressed in CD34+ stem cells in normal tissues, and many more CD34+ cells expressing PADI4 are present in tumour tissues. These findings suggest that PADI4 may play an important role in tumourigenesis.

引用

页数：6

共 66 条

[1] Autoantibodies in rheumatoid arthritis: association with severity of disease in established RA [J].

Agrawal, Sumeet ;

Misra, Ramnath ;

Aggarwal, Amita .

CLINICAL RHEUMATOLOGY, 2007, 26 (02) :201-204

[2] Citrullination: the loss of tolerance and development of autoimmunity in rheumatoid arthritis [J].

Alivernini, S. ;

Fedele, A. L. ;

Cuoghi, I. ;

Tolusso, B. ;

Ferraccioli, G. .

REUMATISMO, 2008, 60 (02) :85-94

[3] Peptidylarginine deiminase 4 and citrullination in health and disease [J].

Anzilotti, Consuelo ;

Pratesi, Federico ;

Tommasi, Cristina ;

Migliorini, Paola .

AUTOIMMUNITY REVIEWS, 2010, 9 (03) :158-160

[4] Structural basis for Ca2+-induced activation of human PAD4 [J].

Arita, K ;

Hashimoto, H ;

Shimizu, T ;

Nakashima, K ;

Yamada, M ;

Sato, M .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2004, 11 (08) :777-783

[5]

Asaga H, 2001, J LEUKOCYTE BIOL, V70, P46

[6] Defining the Role of Integrin αvβ6 in Cancer [J].

Bandyopadhyay, A. ;

Raghavan, S. .

CURRENT DRUG TARGETS, 2009, 10 (07) :645-652

[7] Clinical utility of cytokeratins as tumor markers [J].

Barak, V ;

Goike, H ;

Panaretakis, KW ;

Einarsson, R .

CLINICAL BIOCHEMISTRY, 2004, 37 (07) :529-540

[8] Proteomics implicates peptidyl arginine deiminase 2 and optic nerve citrullination in glaucoma pathogenesis [J].

Bhattacharya, Sanjoy K. ;

Crabb, John S. ;

Bonilha, Vera L. ;

Gu, Xiaorong ;

Takahara, Hidenari ;

Crabb, John W. .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2006, 47 (06) :2508-2514

[9] Modulation of peptidyl arginine deiminase 2 and implication for neurodegeneration [J].

Bhattacharya, Sanjoy K. ;

Bhat, Manjunatha B. ;

Takahara, Hidenari .

CURRENT EYE RESEARCH, 2006, 31 (12) :1063-1071

[10] Steroid hormone receptor in pleural solitary fibrous tumours and CD34+ progenitor stromal cells [J].

Bongiovanni, M ;

Viberti, L ;

Pecchioni, C ;

Papotti, M ;

Thonhofer, R ;

Popper, HH ;

Sapino, A .

JOURNAL OF PATHOLOGY, 2002, 198 (02) :252-257

← 1 2 3 4 5 6 7 →