Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1

被引：64
作者：
Rodriguez-Martinez, J. M.
Velasco, C.
Garcia, I.
Cano, M. E.
Martinez-Martinez, L.
Pascual, A.
机构：
[1] Univ Seville, Dept Microbiol, E-41009 Seville, Spain
[2] Univ Hosp Virgen Macarena, Microbiol Serv, Seville, Spain
[3] Univ Hosp Marques Valdecilla, Microbiol Serv, Santander, Spain
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 06期
关键词：
D O I：
10.1128/AAC.01444-06
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The influence of qnrA1 on the development of quinolone resistance in Enterobacteriaceae was evaluated by using the mutant prevention concentration parameter. The expression of qnrA1 considerably increased the mutant prevention concentration compared to strains without this gene. In the presence of qnrA1, mutations in gyrA and parC genes were easily selected to produce high levels of quinolone resistance.
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页码：2236 / 2239
页数：4
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