Palladium-and/or Copper-Catalyzed Cross-Coupling Reactions of Paramagnetic Vinyl Bromides and Iodides

被引：6
|
作者：
Ur, Gyorgyi [1 ]
Fekete, Gergely Gulyas [2 ]
Jeko, Jozsef [3 ]
Hideg, Kalman [1 ]
Kalai, Tamas [1 ,4 ]
机构：
[1] Univ Pecs, Inst Organ & Med Chem, Szigeti St 12, H-7624 Pecs, Hungary
[2] Univ Pecs, Inst Pharmacognosy, Rokus St 2, H-7624 Pecs, Hungary
[3] Univ Nyiregyhaza, Dept Chem, Sostoi St 31-B, H-4440 Nyiregyhaza, Hungary
[4] Szentagothai Res Ctr, Ifjusag St 20, H-7624 Pecs, Hungary
来源：
SYNTHESIS-STUTTGART | 2017年 / 49卷 / 16期
关键词：
cross-coupling reactions; free radicals; pyridines; pyrimidines; sulfonamides; SPIN-LABELED PROTEINS; NITROXIDES; NITROXYLS; RADICALS; BLOCK; ACID;
D O I：
10.1055/s-0036-1589034
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of new 3-substituted-4-iodo-(2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-1-yl) oxidanyl compounds is synthesized to achieve NH2- and SH-specific spin labels. The new vinyl iodides are tested in Sonogashira and Buchwald-Hartwig cross-coupling reactions to produce a paramagnetic beta-amino acid ester, pyrroline nitroxide-condensed heterocycles, including a paramagnetic a, alpha,alpha'-dipyridyl ligand and a spin-labeled sulfonamide.
引用
收藏
页码：3740 / 3748
页数：9
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