Risk factors predictive of occult cancer detection in patients with unprovoked venous thromboembolism

被引：54

作者：

Ihaddadene, Ryma ^{[1
,2
]}

Corsi, Daniel J. ^{[2
]}

Lazo-Langner, Alejandro ^{[3
,4
]}

Shivakumar, Sudeep ^{[5
,6
]}

Zarychanski, Ryan ^{[7
,8
]}

Tagalakis, Vicky ^{[9
,10
]}

Solymoss, Susan ^{[11
,12
,13
]}

Routhier, Nathalie ^{[14
,15
]}

Douketis, James ^{[16
,17
]}

Le Gal, Gregoire ^{[1
,2
,18
]}

Carrier, Marc ^{[1
,2
,18
]}

机构：

[1] Univ Ottawa, Dept Med, Ottawa, ON, Canada

[2] Ottawa Hosp Res Inst, Ottawa, ON, Canada

[3] Univ Western Ontario, Dept Med, London, ON, Canada

[4] Univ Western Ontario, Dept Epidemiol & Biostat, London, ON, Canada

[5] Queen Elizabeth 2 Hlth Sci Ctr, Dept Hematol, Halifax, NS, Canada

[6] Dalhousie Univ, Dept Med, Halifax, NS, Canada

[7] Univ Manitoba, Dept Med, Winnipeg, MB, Canada

[8] CancerCare Manitoba, Dept Hematol & Med Oncol, Winnipeg, MB, Canada

[9] Sir Mortimer B Davis Jewish Hosp, Dept Med, Montreal, PQ H3T 1E2, Canada

[10] Lady Davis Inst, Ctr Clin Epidemiol, Montreal, PQ, Canada

[11] McGill Univ, Dept Med, Montreal, PQ, Canada

[12] Montreal Gen Hosp, Div Hematol, Montreal, PQ H3G 1A4, Canada

[13] St Marys Hosp, Montreal, PQ, Canada

[14] Univ Montreal, Dept Med, Montreal, PQ H3C 3J7, Canada

[15] Sacre Coeur Hosp, Montreal, PQ, Canada

[16] St Josephs Healthcare Hamilton, Hamilton, ON, Canada

[17] McMaster Univ, Dept Med, Hamilton, ON, Canada

[18] Ottawa Hosp, Ottawa, ON K1H 8L6, Canada

来源：

BLOOD | 2016年 / 127卷 / 16期

关键词：

CASE-FATALITY RATES; PULMONARY-EMBOLISM; POPULATION; THROMBOSIS; DIAGNOSIS; EVENTS;

D O I：

10.1182/blood-2015-11-682963

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Risk factors predictive of occult cancer detection in patients with a first unprovoked symptomatic venous thromboembolism (VTE) are unknown. Cox proportional hazard models and multivariate analyses were performed to assess the effect of specific risk factors on occult cancer detection within 1 year of a diagnosis of unprovoked VTE in patients randomized in the Screening for Occult Malignancy in Patients with Idiopathic Venous Thromboembolism (SOME) trial. A total of 33 (3.9%; 95% CI, 2.8%-5.4%) out of the 854 included patients received a new diagnosis of cancer at 1-year follow-up. Age >= 60 years (hazard ratio [HR], 3.11; 95% CI, 1.41-6.89; P = .005), previous provoked VTE (HR, 3.20; 95% CI, 1.19-8.62; P = .022), and current smoker status (HR, 2.80; 95% CI, 1.24-6.33; P = .014) were associated with occult cancer detection. Age, prior provoked VTE, and smoking status may be important predictors of occult cancer detection in patients with first unprovoked VTE.

引用

页码：2035 / 2037

页数：3

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